Morpholine- and Thiomorpholine-Based Amidodithiophosphonato Nickel Complexes: Synthesis, Characterization, P-N Cleavage, Antibacterial Activity and Silica Nano-Dispersion

Podda, Enrico
Membro del Collaboration Group
;
Carla Aragoni, M
Membro del Collaboration Group
;
Arca, Massimiliano
Membro del Collaboration Group
;
Atzeni, Giulia
Membro del Collaboration Group
;
Ennas, Guido
Membro del Collaboration Group
;
Isaia, Francesco
Membro del Collaboration Group
;
Lippolis, Vito
Membro del Collaboration Group
;
Orru, Germano
Membro del Collaboration Group
;
Scano, Alessandra
Membro del Collaboration Group
;
Pintus, Anna
Membro del Collaboration Group
;
Scano, Alessandra
Membro del Collaboration Group
2021

Abstract

: The reactivity of thiomorpholinium P-(4-methoxyphenyl)-N-thiomorpholin-amidodithiophosphonate (S-MorH+₂)(S-Mor-adtp-) and morpholinium P-(4-methoxyphenyl)-N-morpholin-amidodithiophosphonate (O-MorH+₂)(O-Mor-adtp-) towards nickel (II) dichloride hexahydrated is presented and the hydrolysis of the relevant metal complexes investigated. The hydrolytic products (S-MorH+₂)₂ [Ni(dtp)₂]²- and (O-MorH+₂)₂[Ni(dtp)₂]²- were characterized by means of FT-IR, 1H, and 31P NMR and XRD and the experimented P-N cleavage investigated and elucidated by means of DFT calculations. The antimicrobial activity of the neutral nickel complex [Ni(S-Mor-adtp)₂] was tested against a set of Gram-positive and Gram-negative bacteria alongside with its nanodispersion in a silica matrix. The complex [Ni(S-Mor-adtp)₂] did not show antibacterial activity, whilst the nano-dispersed sample [Ni(S-Mor-adtp)₂]_SiO₂ demonstrated inhibition to growth of Staphylococcus aureus. The nanocomposites were fully characterized by means of XRPD, TGA, SEM and dinitrogen sorption techniques.
2021
Inglese
21
5
2879-2891
2891
13
Esperti anonimi
internazionale
scientifica
Nickel complexes, Amidodithiophosphonato, P–N Cleavage, DFT Calculations, Antibacterial Activity, Nano-dispersion.
Goal 3: Good health and well-being for people
Podda, Enrico; Carla Aragoni, M; Arca, Massimiliano; Atzeni, Giulia; Coles, Simon J; Ennas, Guido; Isaia, Francesco; Lippolis, Vito; Orru, Germano; Scano, Alessandra; Orton, James B; Pintus, Anna; Scano, Alessandra
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
13
none
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