Titolo:  Multifunctional cubic liquid crystalline nanoparticles for chemo and photodynamic synergistic cancer therapy
Data di pubblicazione:  2020
Data di prima pubblicazione on-line:  2020
Autori:  Jenni, Sébastien; Picci, Giacomo; Fornasier, Marco; Mamusa, Marianna; Schmidt, Judith; Talmon, Yeshayahu; Sour, Angélique; Heitz, Valérie; Murgia, Sergio; Caltagirone, Claudia
Numero degli autori:  10
Lingua:  Inglese
Presenza coautori internazionali: 
Volume:  19
Pagina iniziale:  674
Pagina finale:  680
Numero di pagine:  7
Digital Object Identifier (DOI):  http://dx.doi.org/10.1039/c9pp00449a
Codice identificativo Pubmed:  32314755
Codice identificativo Scopus:  2-s2.0-85085263947
Codice identificativo ISI:  WOS:000536853800007
URL:  https://pubs.rsc.org/en/content/articlelanding/2020/PP/C9PP00449A#!divAbstract
Abstract:  With the aim of engineering multifunctional nanoparticles useful for cancer therapy, a diketopyrrolopyr-role-porphyrin based photosensitizer was here conjugated to a block copolymer (Pluronic F108), andused to stabilize in water lipidic cubic liquid crystalline nanoparticles (cubosomes), also loaded with theantineoplastic agent docetaxel. The physicochemical characterization by SAXS, DLS, and cryo-TEMdemonstrated that the formulation consisted of cubosomes, about 150 nm in size, possessing a bicontin-uous cubic structure (space groupPn3m). The cellular imaging experiments proved that these nano-particles localized in lysosomes and mitochondria, while cytotoxicity tests evidenced a slight but signifi-cant synergistic effect which, after irradiation, increased the toxicity induced by docetaxel alone, allowingfurther reduction of cell viability.
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