Titolo:  Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis
Autori: 
Data di pubblicazione:  2005
Rivista: 
ZEITSCHRIFT FUR NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES  
Abstract:  Bioactivity-guided fractionation of the methanol extract from the leaves of Santolina insularis led to the isolation of one new xanthone, (E)-3-{6-[(E)-3-hydroxy-3-oxo-1-propenyl]-9-oxo-9H-xanthen-2-yl}-2-propenoic acid, together with six known flavonoids: hispidulin, nepetin, cirsimaritin, rhamnocitrin, luteolin and luteolin 7-O-beta-D-glucopyranoside. The structures were elucidated by means of 1D-, 2D-NMR spectroscopy and mass spectrometry. The topical anti-inflammatory activity of all isolated compounds and extracts was investigated employing the croton oil-induced dermatitis in mouse ear. The most active compound, luteolin, showed an ID50 of 0.3 mu mol/cm(2) and prevented ear oedema more effectively than an equimolar dose of indomethacin within 24.
Handle:  http://hdl.handle.net/11584/108666
Tipologia: 1.1 Articolo in rivista

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