Titolo:  Cytotoxic diacetylenic spiroketalenol ethers from Plagius flosculosus
Autori: 
Data di pubblicazione:  2006
Rivista: 
JOURNAL OF NATURAL PRODUCTS  
Abstract:  Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds(4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC50 values ranging from 4 to 6 íM.
Handle:  http://hdl.handle.net/11584/106626
Tipologia: 1.1 Articolo in rivista

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