Titolo:  Drug addiction as a disorder of associative learning. Role of nucleus accumbens shell/extended amygdala dopamine
Data di pubblicazione:  1999
Autori: 
Autori:  Di Chiara G.; Tanda G.; Bassareo V.; Pontieri F.; Acquas E.; Fenu S.; Cadoni C.; Carboni E.
Numero degli autori:  8
Lingua:  Inglese
Presenza coautori internazionali:  no
Rivista:  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume:  877
Pagina iniziale:  461
Pagina finale:  485
Numero di pagine:  25
Digital Object Identifier (DOI):  http://dx.doi.org/10.1111/j.1749-6632.1999.tb09283.x
Codice identificativo Pubmed:  10415665
Codice identificativo Scopus:  2-s2.0-0032814694
Codice identificativo ISI:  000081586500026
Parole Chiave:  addiction, associative learning, nucleus accumbens, dopamine, drugs of abuse,
Abstract:  Conventional reinforcers phasically stimulate dopamine transmission in the nucleus accumbens shell. This property undergoes one-trial habituation consistent with a role of nucleus accumbens shell dopamine in associative learning. Experimental studies with place- and taste-conditioning paradigms confirm this role. Addictive drugs share with conventional reinforcers the property of stimulating dopamine transmission in the nucleus accumbens shell. This response, however, undergoes one-trial habituation in the case of conventional reinforcers but not of drugs. Resistance to habituation allows drugs to repetitively activate dopamine transmission in the shell upon repeated self-administration. This process abnormally facilitates associative learning, leading: to the attribution of excessive motivational value to discrete stimuli or contexts predictive of drug availability. Addiction Is therefore the expression of the excessive control over behavior acquired by drug-related stimuli as a result of abnormal strenghtening of stimulus-drug contingencies by nondecremental drug-induced stimulation of dopamine transmission in the nucleus accumbens shell.
Tipologia: 1.1 Articolo in rivista

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