Titolo:  Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat
Data di pubblicazione:  1982
Autori:  Columbano A; Ledda G M; Rao P M; Rajalakshmi S; Sarma D S
Numero degli autori:  5
Volume:  16
Fascicolo:  2
Pagina iniziale:  191
Pagina finale:  196
Numero di pagine:  6
Digital Object Identifier (DOI):  http://dx.doi.org/10.1016/0304-3835(82)90060-X
Codice identificativo Pubmed:  6127157
Abstract:  It was observed that orotic acid (OA), a precursor for pyrimidine nucleotide biosynthesis, when supplied exogenously at 1% level in the diet selectively stimulated the growth of hepatocytes modified by 1,2-dimethylhydrazine (1,2-DMH) to form gamma-glutamyltransferase (gamma-GT) (EC positive islands. Increasing the duration of OA diet from 5 to 10 weeks resulted in an increase in the number of foci from 6 to 14/cm2. Rats that received the carcinogen and basal diet, however, developed only 1-2 foci/cm2. This unique effect of OA can be further accentuated by supplying a liver cell proliferative stimulus, such as a single necrogenic dose of CCl4.
Tipologia: 1.1 Articolo in rivista

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