Titolo:  Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat
Autori: 
Data di pubblicazione:  1982
Rivista: 
CANCER LETTERS  
Abstract:  It was observed that orotic acid (OA), a precursor for pyrimidine nucleotide biosynthesis, when supplied exogenously at 1% level in the diet selectively stimulated the growth of hepatocytes modified by 1,2-dimethylhydrazine (1,2-DMH) to form gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) positive islands. Increasing the duration of OA diet from 5 to 10 weeks resulted in an increase in the number of foci from 6 to 14/cm2. Rats that received the carcinogen and basal diet, however, developed only 1-2 foci/cm2. This unique effect of OA can be further accentuated by supplying a liver cell proliferative stimulus, such as a single necrogenic dose of CCl4.
Handle:  http://hdl.handle.net/11584/98175
Tipologia: 1.1 Articolo in rivista

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