Titolo:  The MPTP/probenecid model of progressive Parkinson's disease.
Data di pubblicazione:  2013
Autori:  Carta, Annarosa; Carboni, Ezio; Spiga, Saturnino
Numero degli autori:  3
Lingua:  Inglese
Volume:  964
Pagina iniziale:  295
Pagina finale:  308
Numero di pagine:  14
Digital Object Identifier (DOI):  10.1007/978-1-62703-251-3_17
Codice identificativo Scopus:  2-s2.0-84878643838
Titolo del libro:  Dopamine: Methods and protocols
Editore:  Humana Press - Springer
ISBN:  978-1-62703-250-6
Abstract:  Parkinson's disease (PD) is characterized by a progressive degeneration of dopamine (DA) neurons and a chronic loss of motor functions. The investigation of progressive degenerative mechanisms and possible neuroprotective approaches for PD depends upon the development of an experimental animal model that reproduces the neuropathology observed in humans. This chapter describes the generation of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTPp) chronic mouse model of PD. This model displays key features of PD, including impairment of motor and olfactory functions associated with partial loss of tyrosine hydroxylase-positive neurons and DA levels in the brain. The MPTPp mouse model provides an important tool for the study of mechanisms contributing to the pathological dysfunction of PD at the cellular and whole animal level.
Parole chiave:  Model, MPTP, Parkinson, Primate, Rodent
Revisione (peer review):  Esperti anonimi
Caratterizzazione prevalente:  scientifica
Rilevanza:  internazionale
Tipologia: 2.1 Contributo in volume (Capitolo o Saggio)

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