Titolo:  Liver hyperplasia and regression after lead nitrate administration
Data di pubblicazione:  1984
Autori: 
Autori:  Columbano A; Ledda-Columbano G M; Coni P P; Vargiu M; Faa G; Pani P
Numero degli autori:  6
Lingua:  Inglese
Rivista:  TOXICOLOGIC PATHOLOGY
Volume:  12
Fascicolo:  1
Pagina iniziale:  89
Pagina finale:  95
Numero di pagine:  7
Codice identificativo Pubmed:  6494739
Abstract:  The effect of a single intravenous injection of lead nitrate on liver, was investigated in male Wistar rats. Lead nitrate at 5 and 10 mumoles/100 g of body weight stimulated a 19-fold increase in the incorporation of 3H-thymidine into liver DNA and resulted in temporal changes in DNA synthesis, as determined by assays of specific activity. Thirty-six hours after lead nitrate administration, the incorporation of 3H-thymidine reached its maximum and returned to normal levels within 3 days. A significant increase in the number of cells entering mitosis at 36 hours indicated the capacity of lead to stimulate liver cell proliferation. Enlargement of the liver after lead treatment was also observed in both female Wistar rats as well in male Fischer rats. This stimulatory effect of lead on liver growth was reversible; during the involution of the liver, cell death morphologically similar to the one described as apoptosis was observed in histological sections of liver from animals sacrificed 4-7 days after lead treatment.
Tipologia: 1.1 Articolo in rivista

File in questo prodotto:
Non ci sono file associati a questo prodotto.

Questionario e social

Condividi su: