Titolo:  HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth.
Autori: 
Data di pubblicazione:  1987
Rivista: 
TOXICOLOGIC PATHOLOGY  
Citazione:  HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth. / Columbano A; Dessi S; Ledda-Columbano G M; Chiodino C; Coni P; Pani P; Rao K N. - In: TOXICOLOGIC PATHOLOGY. - ISSN 0192-6233. - 15:1(1987), pp. 43-50.
Abstract:  Previous studies from our laboratories have shown a stimulation of HMP-shunt, cholesterol metabolism and DNA synthesis during cell proliferation. In order to understand the co-ordinated regulation of these pathways during cell growth, the above metabolic pathways were studied in: liver regeneration after partial hepatectomy, lead-induced liver hyperplasia, liver cell proliferation induced by insulin in streptozotocin-diabetic rats, liver cell proliferation in fasted rats after refeeding and, hepatocyte nodules induced by a selection procedure. The results indeed indicate that changes in HMP-shunt and cholesterol metabolism occur at a very early stage during the process of normal as well as preneoplastic cell growth. The coordinated regulation between cell growth and changes in these metabolic pathways needs further study.
Handle:  http://hdl.handle.net/11584/100747
Tipologia: 1.1 Articolo in rivista

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