Dipartimento di Scienze biomediche

AMEDEO COLUMBANO
FULL PROFESSOR OF PATHOLOGY
DEPARTMENT OF BIOMEDICAL SCIENCES
UNIT OF ONCOLOGY AND MOLECULAR PATHOLOGY
tel. (070) 6758345
FAX (070) 666062;
e-mail:columbano@unica.it

TEACHING ACTIVITIES
Patologia generale e Fisopatologia, CdL Medicina e Chirurgia
Patologia, Immunologia e Patologia Clinica, CdL Scienze Infermieristiche
Insegnamenti di Patologia Generale e di Oncologia in diverse Scuole di Specializzazione

A. POSITIONS
1975-78 Post-doctoral Fellow, RAS, Inst. of General Pathology, School of Medicine, University of Cagliari, Italy
1978-81 Post-doctoral Fellow, Department of Pathology, University of Toronto, Canada
1975-79 Research Associate, Inst. of Pharmacology and Biochemical Patology, School of Medicine University of Cagliari, Italy
1983 Visiting Assistant Professor, Dept. of Pathology, University of Toronto, Canada
1986 Visiting Assistant Professor, Department of Pathology, University of Toronto, Canada
June-September 1988 Visiting Professor, Dept. of Pathology, University of Toronto, Canada
1990 Professor of Pathology, Dept. of Toxicology, School of Medicine, University of Cagliari
June-October 1992 Visiting Professor, Dept. Oncological Pathology, Nara Medical School, Nara, Japan.
June-August 1995 Visiting Professor, Dept. of Pathology, School of Medicine, University of Pittsburgh
1997-98 President of the Teaching Committee (Dental School, University of Cagliari)
1998-2006 President of the Teaching Committee (School of Medicine and Surgery), University of Cagliari
1998-2006 Director of the PhD program in Pathology and Environmental Toxicology, University of Cagliari
2006-2016 Coordinator of the International Exchange Program of the School of Medicine
2006-2009 Director of the PhD program in Toxicology
2009-2012 Chairman of the Department of Toxicology
2012-2015 Member of the Academic Senate of the University of Cagliari
2015- Director of the PhD program in Molecular and Translational Medicine, University of Cagliari

 

MEMBERSHIP SOCIETIES
European Association for Cancer Research (EARC)
American Association for Cancer Research (AACR)
American Association for the Study of Liver Disease (AASLD)
Società Italiana di Patologia e Medicina Traslazionale (SIPMeT)
Società Italiana di Cancerologia (SIC)

OTHER ACTIVITIES
Member of the Scientific Committee of the Associazione Italiana Ricerca sul Cancro (AIRC)
Reviewer of AIRC research proposals
Reviewer of research proposals of Ministero dell’Università e della Ricerca Scientifica, Rome Italy
Reviewer of scientific proposals for the French National Cancer Institute,
Reviewer of scientific projects for the Institut National de la Santè et de la Recherche Medical (INSERM)
Reviewer of scientific research projects for the International Union against Cancer
Reviewer of scientific projects for Wellcome Trust

REFEREE OF THE FOLLOWING JOURNALS
Endocrinology, J Clin Invest, Cancer Research, Carcinogenesis, Hepatology, Journal of Hepatology, Gastroenterology, International Journal of Cancer, Cell Death and Differentiation, American Journal of Pathology, Virchows Cell Archives, Experimental Cell Research, The Histochemical Journal, Journal of Hepatology, J. Free Radical Research, FEBS Letters, and others.

B. SELECTED PUBLICATIONS (last 10 years)
1. Perra A, Simbula G, Simbula M, Pibiri M, Kowalik MA, Sulas P, Cocco MT, Ledda-Columbano GM, Columbano A. Thyroid hormone (T3) and TR{beta} agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB J. 2008 8:2981-2989
2. Columbano A, Simbula M, Pibiri M, Perra A, Deidda M, Locker J, Pisanu A, Uccheddu A, Ledda-Columbano G.M. Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration. Cell Prolif 2008,.41: 521-531
3. Perra A, Pibiri M, Sulas P, Simbula G, Ledda-Columbano G.M., Columbano A. Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model. Carcinogenesis. 2008, 29:161-168
4. Perra A, Simbula G, Simbula M, Pibiri M, Kowalik M.A, Sulas P, Cocco M.T, Ledda-Columbano G.M., Columbano A. Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB J. 2008,. 8: 2981-2989
5. Perra A, Kowalik MA, Pibiri M, Ledda-Columbano GM, Columbano A. Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype. Hepatology 2009, 49:1287-1296
6. Andersen JB, Loi R, Perra A, Factor VM, Ledda-Columbano GM, Columbano A, Thorgeirsson SS. Progenitor-derived hepatocellular carcinoma model in the rat. Hepatology. 2010;51:1401-1409.
7. Kowalik MA, Perra A, Pibiri M, Cocco MT, Samarut J, Plateroti M, Ledda-Columbano GM, Columbano A. TRbeta-is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells. J Hepatol. October 2010; 53:686-692
8. Kowalik MA, Saliba C, Pibiri M, Perra A, Ledda-Columbano GM, Sarotto I, Ghiso E, Giordano S, Columbano A. YAP regulation of adaptive liver enlargement and HCC development. Hepatology. 2011, 53:2086-2096 9. Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober OMV, Ravo M, Weisz A, Locker J, Ghiso E, Giordano S, Columbano A. Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3. J Hepatol. 2011;55:1069-1078 10. Tian J, Huang H, Hoffman B, Liebermann DA, Ledda-Columbano GM, Columbano A, Locker J. Gadd45? is an inducible coactivator of transcription that facilitates rapid liver growth in mice. J Clin Invest. 2011; 121:4491-502 11. Severino V, Locker J, Ledda-Columbano GM, Columbano A, Parente A, Chambery A. Proteomic characterization of early changes induced by triiodothyronine in rat liver. J Proteome Res. 2011,10:3212-3224. 12. Petrelli A, Perra A, Schernhuber K, Cargnelutti M, Salvi A, Migliore C, Ghiso E, Benetti A, Barlati S, Ledda-Columbano GM, Portolani N, De Petro G, Columbano A, Giordano S. Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression. Oncogene. 2012 ;31:4517-4526 13. Migliore C, Martin V, Leoni VP, Restivo A, Atzori L, Petrelli A, Isella C, Zorcolo L, Sarotto I, Casula G, Comoglio PM, Columbano A, Giordano S. MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer. Clin Cancer Res. 2012, 18:737-747. 14. Giordano S, Columbano A. MicroRNAs: New tools for diagnosis, prognosis and therapy in HCC? Hepatology. 2013, 57:840-847 15. Fanti M, Singh S, Ledda-Columbano GM, Columbano A, Monga SP. Triiodothyronine Induces hepatocyte proliferation by protein kinase A-dependent-b-catenin activation in rodents. Hepatology. 2014;59:2309-2320. 16. Giordano S, Columbano A. Met as a therapeutic target in HCC: Facts and hopes. J Hepatol. 2014;60:442-452. 17. Petrelli A, Perra A, Cora D, Sulas P, Menegon S, Manca C, Migliore C, Kowalik MA, Ledda-Columbano GM, Giordano S, Columbano A. MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC). Hepatology. 2014;59:228-241 18. Rizzo F, Hashim A, Marchese G, Ravo M, Tarallo R, Nassa G, Giurato G, Rinaldi A, Cordella A, Persico M, Sulas P, Perra A, Ledda-Columbano GM, Columbano A,Weisz A. Timed regulation of PIWI-interacting RNAs expression during rat liver regeneration. Hepatology. 2014; 60:798-806. 19. Perra A, Kowalik MA, Ghiso E, Ledda-Columbano GM, Di Tommaso L, Angioni MM, Raschioni C, Testore E, Roncalli M, Giordano S, Columbano A. YAP activation is an early event and a potential therapeutic target in liver cancer development. J Hepatol 2014;61:1088-1096. 20. Frau C, Loi R, Petrelli A, Perra A, Menegon S, Kowalik MA, Pinna S, Leoni VP, Fornari F, Gramantieri L, Ledda-Columbano GM, Giordano S, Columbano A. Local hypothyroidism favours the progression of rat preneoplastic lesions to HCC. Hepatology 2015;61:249-59. 21. Zavattari P, Perra A, Menegon S, Kowalik MA, Petrelli A, Angioni MM, Follenzi A, Quagliata L, Ledda-Columbano GM, Terracciano L, Giordano S, Columbano A. Nrf2,but not ?-catenin, mutation represents an early event in rat hepatocarcinogenesis. Hepatology. 2015;62:851-62
22. Kowalik MA, Sulas P, Ledda-Columbano GM, Giordano S, Columbano A, Perra A.
Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis. Oncotarget. 2015;6:38749-63 23. Mattu S, Fornari F, Quagliata L, Perra A, Angioni MM, Petrelli A, Menegon S, Morandi A, Chiarugi P, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Columbano A. The metabolic gene HAO2 is down regulated in mouse, rat and human hepatocellular carcinoma and correlates with metastasis and poor survival. J Hepatol 2016;64:891-8. doi: 10.1016/j.jhep.2015.11.029. Epub 2015 Nov 30.
24. Kowalik M, Perra A, Ledda-Columbano GM, Piacentini M, Columbano A, Falasca L. Induction of autophagy promotes the growth of early preneoplastic rat liver nodules . Oncotarget 2016;7:5788-99. doi: 10.18632/oncotarget.6810.
25. Tschuor C, Kachaylo E, Limani P, Raptis DA, Linecker M, Tian Y, Herrmann U,
Grabliauskaite K, Weber A, Columbano A, Graf R, Humar B, Clavien PA. Constitutive
androstane receptor (Car)-driven regeneration protects liver from failure
following tissue loss. J Hepatol. 2016 Jul;65(1):66-74. doi: 10.1016/j.jhep.2016.02.040.
26. Kowalik MA, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, Trevisan E,
Angioni MM, Fornari F, Quagliata L, Ledda-Columbano GM, Gramantieri L,
Terracciano L, Giordano S, Chiarugi P, Rasola A, Columbano A.
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis. Oncotarget 2016 May 31;7(22):32375-93. doi:10.18632/oncotarget.8632.
27. Menegon S, Columbano A, Giordano S. NRF2, a Janus molecule in cancer. Trends Mol Med 2016;7:578-93..
28. Perra A, Plateroti M, Columbano A. T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair. Endocrine-Related Cancer 2016;23: R353-69.
29. Angioni MM, Bellofatto K, Merlin S, Menegon S, Perra A, Petrelli A, Sulas P, Giordano S, Columbano A, Follenzi A. A long term, non tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis. Oncotarget, 2017; 8:15716-15731
30. Kowalik MA, Columbano A, Perra A. Emerging Role of the Pentose Phosphate. Pathway in Hepatocellular Carcinoma. Front Oncol. 2017;7:87.
31. Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, Singh S, Columbano
A, Yu J, Monga SP. Thyroid hormone receptor-beta agonist GC-1 inhibits Met-?-catenin driven hepatocellular cancer. Am J Pathol. 2017 Aug 11. pii:S0002-9440(17)30403-0. doi: 10.1016/j.ajpath.2017.07.005

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