IN/0169 - CHEMICAL BIOENGINEERING

Academic Year 2017/2018

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Objectives

Knowledge of application of transport phenomena, phase and chemical equilibrium, and prime principle of conservation to biomedical processes and systems like the design or testing of extra-corporeal apparatuses and kinetics involved in biomedical devices.
Understanding the influence of operating conditions and contacting systems between phases in biomedical devices, and how to take them into account during design or testing.

Prerequisites

Chmistry. Mathematical Analysis. Transport phenomena in biomedical and living systems. Chemical and Biological kinetics. Thermodynamics.

Contents

Physico-chemical description of biomedical phenomena (osmosis, chemical and phase equilibrium, chemical and biological kinetics). Oxygen transport in blood and tissues. Oxygenators. Immobilized enzyme reactors. Adsportion processes for blood purification. Elements for bioartificial liver and pancreas. Pharmacokinetics. Cryopreservation of biological samples.

Teaching Methods

Lessons 30 hours.
Exercises 20 hurs.

Verification of learning

The final examination consists of an oral exam (45-60’) with questions on the academic program analyzed in class. The student will be asked to demonstrate his capability on every topic addressed during the lessons and exercises in class: write down the mathematical equations describing the system, with the required modeling details (i.e. balancing the level description of the different phenomena involved in a proper way), but also to extend to more complex description when a more detailed simulation is needed; the student will be asked to know and apply the simplifying assumptions typically adopted in a deterministic modeling of biomedical processes, devices and apparatuses, to properly communicate the design options and test results.

Texts

G.A. Truskey, F. Yuan, D.F. Katz, Transport phenomena in biological systems, Pearson Prentice Hall, (2004).
D.O. Cooney, Biomedical Engineering Principles, An introduction to fluid, heat, and mass transport processes, Marcel Dekker, Inc., (1976).
R.L. Fournier, Basic Transport Phenomena in Biomedical Engineering, Taylor and Francis, (1999).
R.E. Notari, Biofarmaceutica e Farmacocinetica, Piccin Editore Padova, (1981).
Lecture notes provided by instructor.