Metal coordination of thymosin β4: Chemistry and possible implications

Lachowicz J. I.;Pichiri G.;Coni P.;Piludu M.
2019

Abstract

Thymosin β4 (Tβ4) was first isolated in the ‘60ies from calf thymus and was initially perceived as a thymic hormone with immunological effects on lymphocytes. It was then identified as a G-actin binding protein, featuring numerous functions in the human body including blood clothing, tissue regeneration, angiogenesis and tumor metastasis. Tβ4 is also involved in anti-inflammatory and neurodegenerative processes. The exact mechanisms of action of Tβ4 are still unknown, and the binding of the G-actin protein cannot itself explain the multi-activity of Tβ4. We hypothesize that the property of Tβ4 regulating the numerous physiological processes involving Tβ4, is its essential metal – binding ability.
eng
396
117
123
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http://www.journals.elsevier.com/coordination-chemistry-reviews/
https://www.sciencedirect.com/science/article/pii/S0010854519301833?via=ihub
Esperti anonimi
internazionale
Scientifica
si
Lachowicz, J. I.; Jaremko, M.; Jaremko, L.; Pichiri, G.; Coni, P.; Piludu, M.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
reserved
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