Showing results 1 to 50 of 117
Title Issue Date Author(s) Journal Publisher
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities 1-Jan-2022 Corona, Angela; Wycisk, Krzysztof; Talarico, Carmine; Manelfi, Candida; Milia, Jessica; Cannalire, Rolando; Esposito, Francesca; Gribbon, Philip; Zaliani, Andrea; Iaconis, Daniela; Beccari, Andrea R.; Summa, Vincenzo; Nowotny, Marcin; Tramontano, Enzo ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE -
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort 1-Jan-2022 Zaliani, Andrea; Vangeel, Laura; Reinshagen, Jeanette; Iaconis, Daniela; Kuzikov, Maria; Keminer, Oliver; Wolf, Markus; Ellinger, Bernhard; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Manelfi, Candida; Herzog, Katja; Jochmans, Dirk; De Jonghe, Steven; Chiu, Winston; Francken, Thibault; Schepers, Joost; Collard, Caroline; Abbasi, Kayvan; Claussen, Carsten; Summa, Vincenzo; Beccari, Andrea R.; Neyts, Johan; Gribbon, Philip; Leyssen, Pieter SCIENTIFIC DATA -
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity 1-Jan-2022 Nizi, Maria Giulia; Persoons, Leentje; Corona, Angela; Felicetti, Tommaso; Cernicchi, Giada; Massari, Serena; Manfroni, Giuseppe; Vangeel, Laura; Barreca, Maria Letizia; Esposito, Francesca; Jochmans, Dirk; Milia, Jessica; Cecchetti, Violetta; Schols, Dominique; Neyts, Johan; Tramontano, Enzo; Sabatini, Stefano; De Jonghe, Steven; Tabarrini, Oriana ACS MEDICINAL CHEMISTRY LETTERS -
ANTIBACTERIAL COATING 1-Jan-2021 Scano, Alessandra; Ennas, Guido; Esposito, Francesca; Tramontano, Enzo; Angius, Fabrizio - -
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen 1-Jan-2021 Kuzikov, Maria; Costanzi, Elisa; Reinshagen, Jeanette; Esposito, Francesca; Vangeel, Laura; Wolf, Markus; Ellinger, Bernhard; Claussen, Carsten; Geisslinger, Gerd; Corona, Angela; Iaconis, Daniela; Talarico, Carmine; Manelfi, Candida; Cannalire, Rolando; Rossetti, Giulia; Gossen, Jonas; Albani, Simone; Musiani, Francesco; Herzog, Katja; Ye, Yang; Giabbai, Barbara; Demitri, Nicola; Jochmans, Dirk; De Jonghe, Steven; Rymenants, Jasper; Summa, Vincenzo; Tramontano, Enzo; Beccari, Andrea R.; Leyssen, Pieter; Storici, Paola; Neyts, Johan; Gribbon, Philip; Zaliani, Andrea ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE -
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions 1-Jan-2021 Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias MOLECULES -
Structural and biochemical analysis of the dual inhibition of mg-132 against sars-cov-2 main protease (Mpro/3clpro) and human cathepsin-l 1-Jan-2021 Costanzi, E.; Kuzikov, M.; Esposito, F.; Albani, S.; Demitri, N.; Giabbai, B.; Camasta, M.; Tramontano, E.; Rossetti, G.; Zaliani, A.; Storici, P. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 1-Jan-2021 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Ialongo, Davide; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto JOURNAL OF MEDICINAL CHEMISTRY -
Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata 1-Jan-2021 Guzzo, Francesca; Russo, Rosita; Sanna, Cinzia; Celaj, Odeta; Caredda, Alessia; Corona, Angela; Tramontano, Enzo; Fiorentino, Antonio; Esposito, Francesca; D’Abrosca, Brigida MOLECULES -
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds. 1-Jan-2021 Sanna, C.; Marengo, A.; Acquadro, S.; Caredda, A.; Lai, R.; Corona, A.; Tramontano, E.; Rubiolo, P.; Esposito, F. PLANTS -
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication 1-Jan-2020 Corona, Angela; Onnis, Valentina; Del Vecchio, Claudia; Esposito, Francesca; Cheng, Yung-Chi; Tramontano, Enzo MOLECULES -
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 1-Jan-2020 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria; De Leo, Alessandro; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Di Maro, Salvatore; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Valenti, Piera; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto ACS MEDICINAL CHEMISTRY LETTERS -
Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture 1-Jan-2020 Pala, Nicolino; Esposito, Francesca; Tramontano, Enzo; Kumar Singh, Pankaj; Sanna, Vanna; Carcelli, Mauro; Haigh, Lisa D.; Satta, Sandro; Mario Sechi, And ACS MEDICINAL CHEMISTRY LETTERS -
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants 1-Jan-2020 Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcelli, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo VIRUSES -
Probing the importance of the g-quadruplex grooves for the activity of the anti-hiv-integrase aptamer t30923 1-Jan-2020 Esposito, V.; Esposito, F.; Pepe, A.; Monterrey, I. G.; Tramontano, E.; Mayol, L.; Virgilio, A.; Galeone, A. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 1-Jan-2020 Esposito, Francesca; Sechi, Mario; Pala, Nicolino; Sanna, Adele; Koneru, Pratibha Chowdary; Kvaratskhelia, Mamuka; Naesens, Lieve; Corona, Angela; Grandi, Nicole; di Santo, Roberto; D'Amore, Vincenzo Maria; Di Leva, Francesco Saverio; Novellino, Ettore; Cosconati, Sandro; Tramontano, Enzo ANTIVIRAL RESEARCH -
Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H 1-Jan-2020 Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler, John A.; Wilson, Jennifer A.; Corona, Angela; Le Grice, Stuart F. J.; Tramontano, Enzo JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY -
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity 1-Jan-2019 Esposito, F.; Ambrosio, F. A.; Maleddu, R.; Costa, G.; Rocca, R.; Maccioni, E.; Catalano, R.; Romeo, I.; Eleftheriou, P.; Karia, D. C.; Tsirides, P.; Godvani, N.; Pandya, H.; Corona, A.; Alcaro, S.; Artese, A.; Geronikaki, A.; Tramontano, E. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY -
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy) 1-Jan-2019 Sanna, Cinzia; Rigano, Daniela; Corona, Angela; Piano, Dario; Formisano, Carmen; Farci, Domenica; Franzini, Genni; Ballero, Mauro; Chianese, Giuseppina; Tramontano, Enzo; Taglialatela-Scafati, Orazio; Esposito, Francesca NATURAL PRODUCT RESEARCH -
Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds 1-Jan-2018 Sanna, C.; Rigano, D.; Cortis, P.; Corona, A.; Ballero, M.; Parolin, C.; Del Vecchio, C.; Chianese, G.; Saccon, E.; Formisano, C.; Tramontano, E.; Esposito, F. PLANT BIOSYSTEMS -
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication 1-Jan-2018 Sanna, Cinzia; Scognamiglio, Monica; Fiorentino, Antonio; Corona, Angela; Graziani, Vittoria; Caredda, Alessia; Cortis, Pierluigi; Montisci, Mariofilippo; Rita Ceresola, Elisa; Canducci, Filippo; Poli, Ferruccio; Tramontano, Enzo; Esposito, Francesca PLOS ONE -
On the S-layer of Thermus thermophilus and the assembling of its main protein SIpA 1-Jan-2018 Farci, Domenica; Farci, Stefano Francesco; Esposito, Francesca; Tramontano, Enzo; Kirkpatrick, Joanna; Piano, Dario BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES -
Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay 1-Jan-2018 Luca Daino, Gian; Frau, Aldo; Sanna, Cinzia; Rigano, Daniela; Distinto, Simona; Madau, Veronica; Esposito, Francesca; Fanunza, Elisa; Bianco, Giulia; Taglialatela-Scafati, Orazio; Zinzula, Luca; Maccioni, Elias; Corona, Angela; Tramontano, Enzo BIOCHEMISTRY -
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops 1-Jan-2018 Virgilio, Antonella; Amato, Teresa; Petraccone, Luigi; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Romero, Raquel; Haider, Shozeb; Gomez-Monterrey, Isabel; Novellino, Ettore; Mayol, Luciano; Esposito, Veronica; Galeone, Aldo SCIENTIFIC REPORTS -
Structure-guided approach identifies a novel class of HIV-1 Ribonuclease H inhibitors: Binding mode insights through magnesium complexation and site-directed mutagenesis studies 1-Jan-2018 Poongavanam, Vasanthanathan; Corona, Angela; Svendsen, Casper; Scipione, Luigi; Grandi, Nicole; Pandolfi, Fabiana; Di Santo, Roberto; Costi, Roberta; Esposito, Francesca; Tramontano, Enzo; Kongsted, Jacob MEDCHEMCOMM -
New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch 1-Jan-2017 Collu, Gabriella; Farci, Domenica; Esposito, Francesca; Pintus, Francesca; Kirkpatrick, Joanna; Piano, Dario PLANT MOLECULAR BIOLOGY -
Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action 1-Jan-2017 Esposito, Francesca; Mandrone, Manuela; Del Vecchio, Claudia; Carli, Ilaria; Distinto, Simona; Corona, Angela; Lianza, Mariacaterina; Piano, Dario; Tacchini, Massimo; Maccioni, Elias; Cottiglia, Filippo; Saccon, Elisa; Poli, Ferruccio; Parolin, Cristina; Tramontano, Enzo PATHOGENS AND DISEASE -
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions 1-Jan-2017 Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto, Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo PATHOGENS AND DISEASE -
S-layer proteins as a source of carotenoids: Isolation of the carotenoid cofactor deinoxanthin from its S-layer protein DR_2577 1-Jan-2017 Farci, Domenica; Esposito, Francesca; El Alaoui, Sabah; Piano, Dario FOOD RESEARCH INTERNATIONAL -
Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion 1-Jan-2017 Grandi, Nicole; Cadeddu, Marta; Pisano, MARIA PAOLA; Esposito, Francesca; Blomberg, Jonas; Tramontano, Enzo MOBILE DNA -
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding 1-Jan-2017 Martini, Riccardo; Esposito, Francesca; Corona, Angela; Ferrarese, Roberto; Ceresola, Elisa Rita; Visconti, Laura; Tintori, Cristina; Barbieri, Alessandro; Calcaterra, Andrea; Iovine, Valentina; Canducci, Filippo; Tramontano, Enzo; Botta, Maurizio CHEMBIOCHEM -
Chelation motifs affecting metal-dependent viral enzymes: N′-acylhydrazone ligands as dual target inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H domain 1-Jan-2017 Carcelli, Mauro; Rogolino, Dominga; Gatti, Anna; Pala, Nicolino; Corona, Angela; Caredda, Alessia; Tramontano, Enzo; Pannecouque, Christophe; Naesens, Lieve; Esposito, Francesca FRONTIERS IN MICROBIOLOGY -
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6 1-Jan-2016 Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Masaoka, T; Maccioni, Elias; Menéndez Arias, L; Alcaro, S; Le Grice, Sfj; Tramontano, Enzo PLOS ONE -
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication 1-Jan-2016 Esposito, Francesca; Carli, Ilaria; Del Vecchio, Claudia; Xu, Lijia; Corona, Angela; Grandi, Nicole; Piano, Dario; Maccioni, Elias; Distinto, Simona; Parolin, Cristina; Tramontano, Enzo PHYTOMEDICINE -
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 1-Jan-2016 Corona, Angela; di Leva, Francesco Saverio; Rigogliuso, Giuseppe; Pescatori, Luca; Madia, Valentina Noemi; Subra, Frederic; Delelis, Olivier; Esposito, Francesca; Cadeddu, Marta; Costi, Roberta; Cosconati, Sandro; Novellino, Ettore; di Santo, Roberto; Tramontano, Enzo ANTIVIRAL RESEARCH -
RhVI1 is a membrane-anchored vacuolar invertase highly expressed in Rosa hybrida L. petals 1-Jan-2016 Farci, Domenica; Collu, Gabriella; Kirkpatrick, Joanna; Esposito, Francesca; Piano, Dario JOURNAL OF EXPERIMENTAL BOTANY -
Inhibition of HIV-1 reverse transcriptase dimerization by small molecules 1-Jan-2016 Tintori, C; Corona, Angela; Esposito, Francesca; Brai, A; Grandi, Nicole; Ceresola, Er; Clementi, M; Canducci, F; Tramontano, Enzo; Botta, M. CHEMBIOCHEM -
Biological activities of aerial parts extracts of Euphorbia characias 1-Jan-2016 Pisano, MARIA BARBARA; Cosentino, Sofia; Viale, Silvia; Spano', Delia; Corona, Angela; Esposito, Francesca; Tramontano, Enzo; Montoro, P; Tuberoso, CARLO IGNAZIO GIOVANNI; Medda, Rosaria; Pintus, Francesca BIOMED RESEARCH INTERNATIONAL -
Inhibitory effect of 2,3,5,6-tetrafluoro-4-[4-(Aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide derivatives on HIV reverse transcriptase associated rnase H activities 1-Jan-2016 Pala, Nicolino; Esposito, Francesca; Rogolino, Dominga; Carcelli, Mauro; Sanna, Vanna; Palomba, Michele; Naesens, Lieve; Corona, Angela; Grandi, Nicole; Tramontano, Enzo; Sechi, Mario INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -
Development and identification of a novel anti-HIV-1 peptide derived by modification of the N-terminal domain of HIV-1 integrase 1-Jan-2016 Sala, M; Spensiero, A; Esposito, Francesca; Scala, Mc; Vernieri, E; Bertamino, A; Manfra, M; Carotenuto, A; Grieco, P; Novellino, E; Cadeddu, Marta; Tramontano, Enzo; Schols, D; Campiglia, P; Gomez Monterrey, Im FRONTIERS IN MICROBIOLOGY -
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 RibonucleaseH Inhibitors 1-Jan-2016 Corona, Angela; Desantis, J; Massari, S; Distinto, Simona; Masaoka, T; Sabatini, Stefano; Esposito, Francesca; Manfroni, G; Maccioni, Elias; Cecchetti, V; Pannecouque, C; Legrice, Sfj; Tramontano, Enzo; Tabarrini, O. CHEMMEDCHEM -
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors 1-Jan-2016 Corona, Angela; Desantis, Jenny; Massari, Serena; Distinto, Simona; Masaoka, Takashi; Sabatini, Stefano; Esposito, Francesca; Manfroni, Giuseppe; Maccioni, Elias; Cecchetti, Violetta; Pannecouque, Christophe; Le Grice, Stuart F. J; Tramontano, Enzo; Tabarrini, Oriana CHEMMEDCHEM -
Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans 1-Jan-2015 Farci, D; Bowler, Mw; Esposito, Francesca; Mcsweeney, S; Tramontano, Enzo; Piano, Dario FRONTIERS IN MICROBIOLOGY -
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors 1-Jan-2015 Xu, L; Grandi, Nicole; Del Vecchio, C; Mandas, D; Corona, Angela; Piano, Dario; Esposito, Francesca; Parolin, C; Tramontano, Enzo JOURNAL OF MICROBIOLOGY -
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments 1-Jan-2015 Tintori, C; Esposito, Francesca; Morreale, F; Martini, R; Tramontano, Enzo; Botta, M. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS -
Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation 1-Jan-2015 Esposito, Francesca; Tintori, C; Martini, R; Christ, F; Debyser, Z; Ferrarese, R; Cabiddu, Gianluigi; Corona, Angela; Ceresola E., R; Calcaterra, A; Iovine, V; Botta, B; Clementi, M; Canducci, F; Botta, M; Tramontano, Enzo CHEMBIOCHEM -
An efficient route to novel uracil-based drug-like molecules 1-Jan-2015 Babkov, Da; Chizhov, Ao; Khandazhinskaya, Al; Corona, Angela; Esposito, Francesca; Tramontano, Enzo; SELEY RADTKE, Kl; Novikov, Ms SYNTHESIS -
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase 1-Jan-2015 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY -
A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35–Associated Inhibition of Double-Stranded RNA–Stimulated, Retinoic Acid–Inducible Gene 1–Mediated Induction of Interferon β 1-Jan-2015 Cannas, V; Daino, Gl; Corona, Angela; Esposito, Francesca; Tramontano, Enzo THE JOURNAL OF INFECTIOUS DISEASES -
Structure-Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain 1-Jan-2015 Cuzzucoli Crucitti, G; Métifiot, M; Pescatori, L; Messore, A; Madia V., N; Pupo, G; Saccoliti, F; Scipione, L; Tortorella, S; Esposito, Francesca; Corona, Angela; Cadeddu, M; Marchand, C; Pommier, Y; Tramontano, Enzo; Costi, R; Di Santo, R. JOURNAL OF MEDICINAL CHEMISTRY -
Showing results 1 to 50 of 117
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