University of Cagliari
| Title: | Dihydroergotoxine potentiation of thioridazine-induced hypomotility |
| Issue Date: | 1986 |
| Internal authors: | |
| Authors: | Morelli M; Franch F; Di Chiara G |
| Number of authors: | 3 |
| Journal: | PHARMACOLOGICAL RESEARCH COMMUNICATIONS |
| Volume: | 18 |
| Issue: | 11 |
| First page: | 1053 |
| Last page: | 1061 |
| Number of pages: | 9 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0031-6989(86)90022-6 |
| Pubmed identifier: | 3797447 |
| Scopus identifier: | 2-s2.0-0022863478 |
| URL: | http://www.sciencedirect.com/science/article/pii/0031698986900226 |
| Abstract: | Dihydroergotoxine (DHET), a dopamine (DA) receptor agonist, induced hypomotility in rats at doses of 0.125-0.5 mg/kg s.c., (-)sulpiride a D-2 receptor antagonist, a dose which did not affect spontaneous activity (10 mg/kg s.c.) counteracted the hypomotility induced by DHET. Thioridazine (THR), a widely used neuroleptic, reduced motility (2.5-10 mg/kg i.p.) when given alone; this effect was potentiated by DHET when the two drugs administered in doses of 1 mg/kg THR/0.05 mg/kg DHET and 2.5 mg/kg THR/0.125 mg/kg DHET; higher doses of THR (5 and 10 mg/kg i.p.) which by themselves induced marked inhibition of motility, were not potentiated by doses of DHET of 0.25 and 0.5 mg/kg s.c. THR and DHET influenced in an opposite manner the levels of DA-metabolites dihydroxyphenylacetic acid and homovanillic acid in the caudate; while THR (1-10 mg/kg i.p.) increased, DHET (0.25-0.5 mg/kg s.c.), decreased DA-metabolite levels. The association of THD and DHET resulted in a reciprocal antagonism of their effects on DA-metabolite levels. |
| Type: | 1.1 Articolo in rivista |
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