Title:  Behavioural expression of D-1 receptor supersensitivity depends on previous stimulation of D-2 receptors
Issue Date:  1987
Internal authors: 
Authors:  Morelli M; Fenu S; Di Chiara G
Number of authors:  3
Journal:  LIFE SCIENCES
Volume:  40
Issue:  3
First page:  245
Last page:  251
Number of pages:  7
Digital Object Identifier (DOI):  http://dx.doi.org/10.1016/0024-3205(87)90339-0
Pubmed identifier:  2948094
Scopus identifier:  2-s2.0-0023078212
URL:  http://www.sciencedirect.com/science/article/pii/0024320587903390
Abstract:  SKF 38393 (2 mg/kg s.c.), a reportedly selective D-1 agonist, failed to induce contralateral turning behaviour in naive rats bearing 12 days old unilateral 6-hydroxydopamine lesions. On the other hand strong contraversive turning in response to SKF 38393 was obtained if rats had been tested 2 or 7 days before with apomorphine (0.1 mg/kg s.c.) or with LY 171555 (0.2 mg/kg s.c.), a selective D-2 receptor agonist. Contraversive turning in response to SKF 38393 was blocked by a low dose (0.05 mg/kg s.c.) of the specific D-1 antagonist SCH 23390. The results indicate that the behavioural expression of D-1 receptor supersensitivity following lesion of dopaminergic neurons depends on previous exposure to a stimulation of D-2 receptors.
Type: 1.1 Articolo in rivista

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