Title:  L-Dopa stimulates c-fos expression in dopamine denervated striatum by conbined activation of D-1 and D-2 receptors
Internal authors: 
Issue Date:  1993
Journal: 
BRAIN RESEARCH  
Citation:  L-Dopa stimulates c-fos expression in dopamine denervated striatum by conbined activation of D-1 and D-2 receptors / Morelli M; Cozzolino A; Pinna A; Fenu S; Carta A; Di Chiara G. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 623:2(1993), pp. 334-336.
Abstract:  Administration Of L-dopa to unilaterally 6-hydroxydopamine-lesioned rats, activates the early gene c-fos in the lesioned caudate-putamen. D-1 receptor blockade by SCH 23390, prevented L-dopa-induced Fos-like immunoreactivity in the whole caudate-putamen, while D-2 receptor blockade by raclopride reduced Fos-like immunoreactivity only in the dorso-lateral portion. The results suggest that L-dopa induces c-fos primarily through an activation of D-1 receptors, while D-2 receptor stimulation plays a facilitatory influence on D-1-mediated c-fos expression.
URI:  http://hdl.handle.net/11584/95765
Type: 1.1 Articolo in rivista

Files in This Item:
There are no files associated with this item.

Questionnaire and social

Share on: