Title:  Destruction of post-synaptic dopamine receptors prevents neuroleptic-induced activation of striatal tyrosine hydroxylase but not dopamine synthesis stimulation.
Internal authors: 
Issue Date:  1978
Journal: 
LIFE SCIENCES  
Abstract:  Destruction of post-synaptic dopamine (DA)-receptors by intrastriatal kainic acid prevents the haloperidol-induced activation of striatal tyrosine-hydroxylase but not the stimulation of DA-synthesis estimated in vivo on the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after inhibition of aromatic aminoacid decarboxylase. The results indicate the existence of two DA-receptor-mediated mechanisms regulating DA-synthesis in vivo: one depending on the presence of post-synaptic DA-receptors and capable of producing a stable activation of tyrosine-hydroxylase whereas the other is not associated to a persistent conformational change of tyrosine-hydroxylase and is possibly mediated by pre-synaptic DA-receptors. The results also indicate that the activation of striatal tyrosine-hydroxylase by neuroleptics is unrelated to blockade of pre-synaptic DA-receptors.
URI:  http://hdl.handle.net/11584/39549
Type: 1.1 Articolo in rivista

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