Title:  [3H]CL 218,872, a novel triazolopyridazine which labels the benzodiazepine receptors in rat brain
Internal authors: 
Issue Date:  1982
Journal: 
EUROPEAN JOURNAL OF PHARMACOLOGY  
Abstract:  We examined the specific binding of [3H]CL 218,872, a novel triazolopyridazine to benzodiazepine receptors in the rat cerebral cortex. Two binding sites with KD values of about 10-30 nM and 200-600 nM were demonstrated. A number of benzodiazepine anxiolytics inhibited [3H]CL 218,872 binding in a manner which correlates with the potency of these drugs for inhibiting [3H]benzodiazepine binding. Our initial studies show that [3H]CL 218,872 can label the benzodiazepine receptors and may prove to be a useful probe for studying benzodiazepine heterogeneity and regulation.
URI:  http://hdl.handle.net/11584/35994
Type: 1.1 Articolo in rivista

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