Title:  [3H]Ro5-4864 benzodiazepine binding in the kainate lesioned striatum and Huntington's diseased basal ganglia
Internal authors: 
Issue Date:  1982
Journal: 
BRAIN RESEARCH  
Citation:  [3H]Ro5-4864 benzodiazepine binding in the kainate lesioned striatum and Huntington's diseased basal ganglia / Schoemaker H; Morelli M; Deshmukh P; Yamamura H I. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 248:2(1982), pp. 396-401.
Abstract:  [3H]Ro5-4864-labeled peripheral-type benzodiazepine binding sites in the brain were studied after kainic acid lesions of the rat striatum. Following intrastrial kainate injections [3H]Ro5-4864 binding increased to approximately 1000% of control over a period of 1 week and was maintained at this level for up to 6 weeks. Two weeks after lesioning the number of binding sites (Bmax) was selectively increased while the dissociation constant (Kd) was only minimally affected. [3H]Ro5-4864 binding in the Huntington's diseased (HD) basal ganglia was not changed as compared to non-neurological control in the caudate nucleus and globus pallidus. A highly significant 51% increase was found in the HD putamen. It is concluded that the peripheral-type, Ro5-4864-sensitive benzodiazepine receptor in the brain may be predominantly localized on glial elements
URI:  http://hdl.handle.net/11584/35984
Type: 1.1 Articolo in rivista

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