Title:  Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy
Issue Date:  1981
Internal authors: 
Authors:  Morelli M; Porceddu M L; Imperato A; Di Chiara G
Number of authors:  4
Journal:  BRAIN RESEARCH
Volume:  217
Issue:  2
First page:  375
Last page:  379
Number of pages:  5
Digital Object Identifier (DOI):  http://dx.doi.org/10.1016/0006-8993(81)90014-7
Pubmed identifier:  6972799
Scopus identifier:  2-s2.0-0019463897
ISI identifier:  MEDLINE:6972799
URL:  http://www.sciencedirect.com/science/article/pii/0006899381900147
Abstract:  Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.
Type: 1.1 Articolo in rivista

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