Title:  Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy
Internal authors: 
Issue Date:  1981
Journal: 
BRAIN RESEARCH  
Citation:  Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induced catalepsy / Morelli M; Porceddu M L; Imperato A; Di Chiara G. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 217:2(1981), pp. 375-379.
Abstract:  Bilateral kainate-induced lesions of the substantia nigra prevented or dramatically reduced the catalepsy produced by haloperidol. In contrast, infusion of 1 or 4 micrograms 6-OHDA in the medial forebrain bundle, which decreased striatal DA by 30% and 80% respectively, failed to affect or actually potentiated haloperidol catalepsy. Since intranigral kainate, in contrast to 6-OHDA, destroys pars reticulata neurons it appears that these neurons are essential for the expression of haloperidol-catalepsy.
URI:  http://hdl.handle.net/11584/109434
Type: 1.1 Articolo in rivista

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