Title:  Blockade of NMDA receptors differentially affects D1 and D2 mediated turning behavior in the 6-hydroxydopamine model of Parkinson
Internal authors: 
Issue Date:  1991
Journal: 
AMINO ACIDS  
Citation:  Blockade of NMDA receptors differentially affects D1 and D2 mediated turning behavior in the 6-hydroxydopamine model of Parkinson / MORELLI M; FENU S; PINNA A; COZZOLINO A; DI CHIARA G. - 1:2(1991), pp. 205-213.
Abstract:  In rats with unilateral lesion of the nigrostriatal dopaminergic pathway, L-DOPA induces contralateral turning through activation of denervated D-1 and D-2 receptors. Blockade of N-methyl-D-aspartate (NMDA) receptors by the non-competitive antagonist (+)MK-801, potentiated the contralateral turning induced by L-DOPA as well as that induced by the D-1 agonist SKF 38393, while D-2 mediated turning was almost completely inhibited. Administration of the D-1 antagonist SCH 23390 blocked (+)MK-801-induced potentiation of L-DOPA contralateral turning, confirming the D-1 nature of the effects observed. Immunohistochemical studies on the early gene c-fos, which is known to be activated by stimulation of supersensitive D-1 receptors, revealed sparse c-fos positive nuclei in the lesioned CPu after SKF 38393, while after combined administration of (+)MK-801 and SKF 38393 dense labelling was obtained. Blockade of NMDA receptors, differentially affects D-1 and D-2 mediated turning behavior, suggesting that different neuronal pathways are involved in the mediation of D-1 and D-2 responses.
URI:  http://hdl.handle.net/11584/108982
Type: 1.1 Articolo in rivista

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