Title:  Direct and indirect striatal efferent pathways are differentially influenced by low and high dyskinetic drugs: behavioural and biochemical evidence
Issue Date:  2008
Internal authors: 
Authors:  CARTA A; FRAU L; PONTIS S; PINNA A; MORELLI M
Number of authors:  5
Journal:  PARKINSONISM & RELATED DISORDERS
Volume:  14
Issue:  Suppl 2
First page:  S165
Last page:  S168
Number of pages:  4
Digital Object Identifier (DOI):  http://dx.doi.org/10.1016/j.parkreldis.2008.04.023
Pubmed identifier:  18583175
Scopus identifier:  2-s2.0-47049130314
URL:  http://www.sciencedirect.com/science/article/pii/S135380200800134X
Abstract:  Clinical evidence suggests that stimulation of the D(1) rather than D(2) dopamine receptor is related to the development of dyskinesias in Parkinson's disease (PD). We evaluated, in the 6-hydroxydopamine rat model of PD, sensitization of contralateral turning (SCT) behaviour and abnormal involuntary movements (AIMs) as behavioural parameters of dyskinetic response, and changes in zif-268 mRNA expression in striatonigral and striatopallidal neurons on subchronic administration of the D(2)/D(3) agonist ropinirole, defined as a mild dyskinetic drug in the clinic. Results were compared with previous findings on repeated L-dopa treatment. Ropinirole displayed a mild dyskinetic response characterized by SCT only, which contrasted with the presence of SCT in association with AIMs elicited by repeated L-dopa. Zif-268 mRNA levels were decreased in both striatonigral and striatopallidal neurons by ropinirole, in contrast to hyper-expression of zif-268 mRNA selectively induced by L-dopa in striatonigral neurons. Unbalanced responsiveness of striatal efferent neurons might represent a molecular correlate of high dyskinetic potential and AIMs in rats; in contrast, a balanced striatal output might underlie the low dyskinetic potential displayed by ropinirole.
Type: 1.1 Articolo in rivista

Files in This Item:
There are no files associated with this item.

Questionnaire and social

Share on: