Title:  Self-inhibitory dopamine-receptors and central effects of apomorphine.
Internal authors: 
Issue Date:  1978
Journal: 
ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ  
Citation:  Self-inhibitory dopamine-receptors and central effects of apomorphine. / Di Chiara G; Porceddu ML; Morelli M; Gessa GL. - 14:1(1978), pp. 111-122.
Abstract:  Apomorphine, a central dopamine-receptor agonist, is well known to produce excitatory effects in animals. However, low doses exert depressant effects as hypomotility, sedation and sleep. The mechanism of these effects are discussed in terms of a stimulation by apomorphine of DA-receptors, different from the post-synaptic ones, provided of an inhibitory effect on DA-synthesis and on the firing of dopaminergic neurons.
URI:  http://hdl.handle.net/11584/103768
Type: 1.1 Articolo in rivista

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