Title:  Evidence that nigral GABA mediates behavioural responses elicited by striatal dopamine receptor stimulation.
Internal authors: 
Issue Date:  1978
Journal: 
LIFE SCIENCES  
Abstract:  Bilateral intranigral administration of GABA-receptor blockers (picrotoxin or bicuculline) elicits catatonia not surmountable by administration of apomorphine, a dopamine (DA)-receptor agonist. Unilateral intranigral administration of GABA-receptor blockers ipsilateral to a lesion of nigro-striatal DA-neurons induced with 60H-DA, antagonizes the contralateral turning produced by apomorphine. The results indicate that behaviouralresponseselicited by striatal DA-receptorstimulation are effected through a GABA-mediated inhibition of pars reticulata neurons.
URI:  http://hdl.handle.net/11584/103724
Type: 1.1 Articolo in rivista

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