Title:  Benzodiazepines prevent kainate-induced loss of GABAergic and cholinergic neurons in the chick retina.
Internal authors: 
Issue Date:  1981
Journal: 
BRAIN RESEARCH  
Citation:  Benzodiazepines prevent kainate-induced loss of GABAergic and cholinergic neurons in the chick retina. / Imperato A; Porceddu M L; Morelli M; Fossarello M; Di Chiara G. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 213:1(1981), pp. 205-210.
Abstract:  Kainic acid (50 nmol), applied intravitreally to the eyes of chicks, produces within 6 h a loss of more than 50% of biochemical markers for cholinergic and GABAergic neurons in the retina. Repeated peripheral administration of benzodiazepines, such as diazepam and clonazepam, protects from the kainate-induced loss of cholinergic and GABAergic markers in the retina. Histologically diazepam reduces the nuclear pyknosis induced by kainate particularly at the level of the amacrine cell-layer.
URI:  http://hdl.handle.net/11584/101695
Type: 1.1 Articolo in rivista

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