Title:  Pathophysiological roles for purines: adenosine, caffeine and urate
Issue Date:  2010
Internal authors: 
Authors:  Morelli, Micaela; Carta, Annarosa; Kachroo, A; Schwarzschild, Ma
Number of authors:  4
Language:  Inglese
Journal:  PROGRESS IN BRAIN RESEARCH
Volume:  183
First page:  183
Last page:  208
Number of pages:  26
Digital Object Identifier (DOI):  10.1016/S0079-6123(10)83010-9
Scopus identifier:  2-s2.0-77955353133
ISI identifier:  WOS:000287859500010
Book title:  Progress in Brain Research-Recent Advances in Parkinson’s Disease: Basic Research
Publisher name:  Björklund A, Cenci M.A.
URL:  http://www.sciencedirect.com/science/article/pii/S0079612310830109
ISBN:  978-0-444-53750-8
Abstract:  The motor symptoms of Parkinson's disease (PD) are primarily due to the degeneration of the dopaminergic neurons in the nigrostriatal pathway. However, several other brain areas and neurotransmitters other than dopamine such as noradrenaline, 5-hydroxytryptamine and acetylcholine are affected in the disease. Moreover, adenosine because of the extensive interaction of its receptors with the dopaminergic system has been implicated in the pathophysiology of the disease. Based on the involvement of these non-dopaminergic neurotransmitters in PD and the sometimes severe adverse effects that limit the mainstay use of dopamine-based anti-parkinsonian treatments, recent assessments have called for a broadening of therapeutic options beyond the traditional dopaminergic drug arsenal. In this review we describe the interactions between dopamine and adenosine receptors that underpin the pre-clinical and clinical rationale for pursuing adenosine A(2A) receptor antagonists as symptomatic and potentially neuroprotective treatment of PD. The review will pay particular attention to recent results regarding specific A(2A) receptor-receptor interactions and recent findings identifying urate, the end product of purine metabolism, as a novel prognostic biomarker and candidate neuroprotectant in PD.
Peer review:  Esperti anonimi
scientifica
Circulation:  internazionale
Type: 2.1 Contributo in volume (Capitolo o Saggio)

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