Title:  Origin of GABA-ergic strio-nigral neurons as studied by kainate-induced lesions
Issue Date:  1980
Internal authors: 
Authors:  Porceddu M L; Morelli M; Del Fiacco M; Di Chiara G
Number of authors:  4
Journal:  PHARMACOLOGICAL RESEARCH COMMUNICATIONS
Volume:  12
Issue:  7
First page:  695
Last page:  698
Number of pages:  4
Digital Object Identifier (DOI):  http://dx.doi.org/10.1016/S0031-6989(80)80107-X
Pubmed identifier:  7403239
Scopus identifier:  2-s2.0-0018936154
Abstract:  Kainic acid was used to clarify the source of nigral GABA-ergic terminals. Rats were microinjected unilaterally with kainic acid in the globus pallidus, head, body and tail of the caudate. Lesions of the pallidus resulted in a non-significative (5.5 %) reduction of nigral GAD. Kainic-lesions of the head of the caudate resulted in a significative (19%) drop of nigral GAD, while lesions of the caudate body resulted in the largest reduction of nigral GAD (53%). Lesions of the caudate tail were without effect. These results indicate that nigral GAD arises mostly from the body and in part, also from the head of the caudate but not from the globus pallidus or from the tail of the caudate.
Type: 1.1 Articolo in rivista

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