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Professor
GIORGIO LA NASA (Tit.)
MARIO SCARTOZZI
OLGA MULAS
ELEONORA LAI
Period
Second Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[40/39]  MEDICINE AND SURGERY [39/00 - Ord. 2015]  PERCORSO COMUNE 8 110

Objectives

BASIC KNOWLEDGE AND COMPREHENSION CAPACITY: The student shall be able to evaluate patients’ health status from the preventive, diagnostic, therapeutic and rehabilitative point of view, and integrate the contributions of systematic pathology and specialized medicine in oncology, hematology and oncohematology fields in a unitary vision of an individual suffering from a specific disease.
APPLICATION CAPACITIES: the student must be able to apply both diagnostic and therapeutic strategies of oncology, hematology and oncohematology diseases. In addition, he is required to critically analyze and evaluate alternative hypothesis and differential diagnosis. The student must therefore be able to rationally and efficiently choose among the available diagnostic tools in order to reach a final and correct diagnosis and to subsequently choose the right therapy.
AUTONOMY JUDGEMENT: The student will learn to acquire and integrate anamnestic and instrumental data in order to formulate a diagnostic judgement in the context of oncology, hematology and oncohematology diseases.
COMMUNICATION CAPACITY: The student will learn to present relevant data regarding a specific clinical case and to properly expose the development of diagnostic pathways and the results of therapeutic interventions.
COMPREHENSION CAPACITY: The student will learn to acquire new information and to enforce his cultural background in a critical way through the consultation and interpretation of recent scientific literature.

Prerequisites

A good knowledge of physiopathology is a fundamental prerequisite to better define the clinical and semeiological characteristics of the various oncological and haematological diseases. Understanding the genetic basis underlying the various oncological and blood lymphoproliferative processes.

Contents

.1) Hematology lesson plan
Hemopoiesis. Hyporegenerative Anemias. Thalassemia syndromes and hemoglobinopathies. Hemolytic Anemias. Bone Marrow Aplasia. Myelodisplasias. Acute Leukemias. Chronic Myeloid Leukemia. Ph- Chronic Myeloproliferative Neoplasias. Hodgkin’s Lymphoma. Non-Hodgkin’s Lymphoma. Chronic Lymphatic Leukemia. Monoclonal Gammopathies. Multiple Myeloma. Stem Cells and logical transplant principles. CID. Thrombocytopenias. Thrombotic Microangiopathies. Problem approach. Urgencies and emergencies in hematology. Clinical cases
2) Oncology lessons plan
Epidemiology of solid tumors: risk factors. Primary and secondary prevention of cancer. Chemoprevention of cancer. Principles of cell proliferation and drug-resistance. Principles of tumor dissemination and metastatization. Tumor staging. General prognostic and predictive factors of cancer. Antiproliferative drugs: class, mechanism of action and toxicity. Targeted agents. Chemotherapy indications: neoadjuvant, adjuvant, curative, palliative setting. Principles regulating controlled clinical trial. Assessment of therapeutic response. Follow-up in Medical Oncology. Breast cancer. Lung cancer. Colorectal cancer. Gynecological Malignancies (cancer of the endometrium, carcinoma of the cervix). Prostate cancer. Neoplasms of the head and neck. Oncological emergencies. Pathogenesi of pain in oncology and treatment. Geriatric Oncology: multidimensional geriatric assessment. Supportive therapies in oncology. Palliative care. Cancer cachexia.
Epidemiology of Cancer and cancer statistics. Primary and secondary prevention, screening programs active and their characteristics. General concepts of staging, TNM. Guidance to medical treatment / surgery / radiotherapy. General concepts on how the overall assessment of the patient with cancer. General Concepts of chemotherapy, combination chemotherapy, single-agent chemotherapy, neo-adjuvant chemotherapy, adjuvant, palliative.Evalutation’s Criteria of response to chemotherapy. Main side effects of chemotherapy drugs. General concepts of clinical trials, experimental trials in vitro, in vivo, studies of phase I, II, III, IV. Geriatric Oncology. Epidemiology, risk factors, diagnosis, pathology, staging, treatment of the following cancers: Breast cancer, lung cancer, colorectal cancer, ovarian, cervix and uterine carncer, head and neck cancer, prostate cancer, bladder cancer, seminomas.

Teaching Methods

The entire course will include both frontal lectures presented thought PowerPoint presentations and clinical practice though the attendance of clinical ward, day hospital, clinic and endoscopy unit. The frontal lecture may be integrated by innovative teaching routes (active learning) through the analysis and interpretation of clinical cases.

Verification of learning

The final exam will be based on a written or oral test.
The written exam will be composed of multiple-choice questions.
The oral exam will include 3 open questions on 3 different topics present on the program that could be also presented as clinical cases. Every answer will be evaluated with a score ranging from 0 to 10.
In both cases, the maximum final grade that could be achieved is 30. The exam will be considered as passed if at least a grade of 18/30 has been achieved.
The comprehension of course covered topics, as well as the ability to formulate valid diagnostic hypothesis and to verify them through an opportune and valuable diagnostic planning, will be evaluated. The knowledge of non specialistic therapies for the examinated pathologies will also be evaluated. Finally, the expression capacity, the use of appropriate scientific language and the ability to synthetize information will be assessed.
The final grade will take into account:
Manifested quality of the knowledge, capacities and competences:
a) Knowledge pertinence, accuracy and consistency
b) Capacity pertinence, accuracy and consistency
c) Competences pertinence, accuracy and consistency
Expository modalities:
a) Expressive capacity.
b) Appropriate and correct use of specific discipline-related language.
c) Logic reasoning capabilities in contents connection.
e) Ability to create links between different topics focusing on common points, and to make a general coherent speech, taking care of the structure, organization and logic connections of the speech.
f) Ability to synthetize information.
The final grade can be:
a) Sufficient (18 to 20/30)
Scarcity of acquired notions, superficial level of knowledge with numerous gaps, simple expressive capacities but sufficient to sustain a coherent speech. The capacity to link different topics lays at an elementary level. Scarce ability to synthetize and to interact with the professor during the interview.
b) Decent (21 to 23)
Reasonable quantity of acquired notions, but scarce in-depth analysis. Few knowledge gaps. Expressive capacities adequate to sustain a coherent speech and acceptable scientific language fluency. The ability to logically link different topics lays at a moderate complexity level. Adequate ability to synthetize and to interact with the professor during the interview.
c) Good (24 to 26)
Wide knowledge, moderate in-depth analysis, with little gaps; satisfying expressive capacities and significative scientific language fluency; well recognizable ability to dialog and acceptable critical sensibility. Good ability to synthetize and to interact with the professor during the interview.
d) Very good (27 to 29)
Extensive and deeply analyzed knowledge, with only negligible gaps; notable expressive capacities and high scientific language fluency; remarkable ability to dialog and inclination to synthetize and to interact with the professor during the interview.
e) Excellent (30)
Exceptionally extensive and deeply analyzed knowledge, eventually with irrelevant gaps. Very high expressive capacities and scientific language fluency, excellent ability to dialog, exceptional inclination to create links between different topics, outstanding ability to synthetize and to interact with the professor during the interview.
The laude will be awarded to the candidates that demonstrate to be remarkably above the average, whose eventual expressional, conceptual, logical and notional limits result to be mainly irrelevant.

Texts

-“MANUALE DI MALATTIE DEL SANGUE" Bosi A., De Stefano V., Di Raimondo F., La Nasa G. Ed. ELSEVIER.
-“LA MEDICINA ONCOLOGICA. Diagnosi, Terapia e gestione clinica. Labianca R., Cascinu S. Edizioni EDRA Italia

More Information

The exam registrations will take place through ESSE3 platform.
The exam could be sustained by all the students who attended at least 70% of the total frontal lectures hours and at least 50% of each lesson module and after a complete attendance of all hours required for the practical professionalizing activity.

Questionnaire and social

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