2644 - GENERAL PATHOLOGY
Academic Year 2021/2022
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ANDREA PERRA (Tit.)
MARTA ANNA KOWALIK
- Teaching style
- Lingua Insegnamento
|[50/22] PHARMACY||[22/00 - Ord. 2014] PERCORSO COMUNE||10||80|
KNOWLEDGE AND UNDERSTANDING CAPACITY
The course is specifically intended to provide students with the basic pathological principles by relating basic science with main pathogenetic mechanisms.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING (COMPETENCE)
At the end of the course students should have a sound knowledge of the fundamental biological and pathological mechanisms underlying human diseases.
The students should be able to use and understand the medical terminology
Emphasis will be also placed on the applications of molecular biology and histopathology and their relevance in the understanding of the origin of diseases.
Biology, Human Anatomy, Biochemistry, Physiology
Cell injury and cell death: Necrosis and apoptosis.
Cellular adaptation of growth and differentiation: Hyperplasia, hypertrophy, atrophy, metaplasia.
Intracellular accumulation: Lipids, proteins, glycogen, pigments.
Control of normal cell growth: cell cycle and the regulation of cell division.
Acute and chronic inflammation.
Vascular changes, cellular events, chemical mediators of inflammation.
Systemic effects of inflammation.
Tissue repair and fibrosis.
Neoplasia. Epidemiology: Cancer incidence. Definition and terminology.
Biology of tumor growth (angiogenesis, progression and heterogeneity, invasion and metastasis).
Carcinogenic agents and their cellular interaction.
DNA damage and repair.
Molecular basis of cancer (Oncogenes, cancer suppressor genes, molecular basis of multistep carcinogenesis).
Mendelian disorders (autosominal dominant, recessive and X-linked).
Biochemical and molecular basis of single-gene disorders.
Diseases of immunity.
Mechanism of immunologic tissue injury: hypersensitivity reactions.
Diabetes: pathogenesis risk factors, complications.
Atherosclerosis: pathogenesis risk factors, complications.
Heart failure and hypertension.
Thrombosis (arterial and venous), embolism, ischemia reperfusion injury.
Pathophysiology of the liver: hepatitis, fatty liver, liver failure.
Qualitative and quantitative blood cells alterations.
Lectures for up to 10 CFU.
Each lecture lasts 2 hours. The weekly lectures are between 3 and 4.
The lessons will be held simultaneously both in class and by online streaming. At the beginning of the semester, each student must opt for face-to-face or online teaching. Shifts will be scheduled depending on the number of students who opt for the class mode.
Verification of learning
At the end of the course students will be subjected to a comprehensive final exam, articulated in a written multiple choice test, followed by an oral examination.
Based on the epidemiological context, the written tests can be replaced by: group monographic papers, oral exam, online written exam. In addition, intermediate exam tests can be eliminated.
Robbins: Le basi patologiche delle malattie. Elsevier;
Pontieri: Patologia Generale Piccin;
Stevens-Lowe: Patologia. Ambrosiana;
Woolf: Patologia Generale.Idelson -Gnocchi;
Rubin: Patologia. Ambrosiana.