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Professor
ANDREA PERRA (Tit.)
MARTA ANNA KOWALIK
Period
Second Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[50/22]  PHARMACY [22/00 - Ord. 2014]  PERCORSO COMUNE 10 80

Objectives

PATHOLOGY MODULE
KNOWLEDGE AND UNDERSTANDING CAPACITY
The course is specifically intended to provide students with the basic pathological principles by relating basic science with main pathogenetic mechanisms.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING (COMPETENCE)
At the end of the course students should have a sound knowledge of the fundamental biological and pathological mechanisms underlying human diseases.
COMMUNICATION SKILLS
The students should be able to use and understand the medical terminology
LEARNING ABILITY
Emphasis will be also placed on the applications of molecular biology and histopathology and their relevance in the understanding of the origin of diseases.

Prerequisites

Requirements:
Biology, Human Anatomy, Biochemistry, Physiology

Contents

Cellular Pathology
Cell injury and cell death: Necrosis and apoptosis.
Cellular adaptation of growth and differentiation: Hyperplasia, hypertrophy, atrophy, metaplasia.
Intracellular accumulation: Lipids, proteins, glycogen, pigments.
Control of normal cell growth: cell cycle and the regulation of cell division.
Acute and chronic inflammation.
Vascular changes, cellular events, chemical mediators of inflammation.
Non-inflammatory edema
Systemic effects of inflammation.
Fever.
Tissue repair and fibrosis.
Wound healing.
Neoplasia. Epidemiology: Cancer incidence. Definition and terminology.
Biology of tumor growth (angiogenesis, progression and heterogeneity, invasion and metastasis).
Carcinogenic agents and their cellular interaction.
DNA damage and repair.
Molecular basis of cancer (Oncogenes, cancer suppressor genes, molecular basis of multistep carcinogenesis).
Genetic disorders.
Mendelian disorders (autosominal dominant, recessive and X-linked).
Biochemical and molecular basis of single-gene disorders.
Cytogenetic disorders.
Diseases of immunity.
Mechanism of immunologic tissue injury: hypersensitivity reactions.
Autoimmune diseases
Pathophysiology.
Diabetes: pathogenesis risk factors, complications.
Atherosclerosis: pathogenesis risk factors, complications.
Heart failure and hypertension.
Thrombosis (arterial and venous), embolism, ischemia reperfusion injury.
Pathophysiology of the liver: hepatitis, fatty liver, liver failure.
Respiratory failure.
Qualitative and quantitative blood cells alterations.

Teaching Methods

Lectures for up to 10 CFU.
Each lecture lasts 2 hours. The weekly lectures are between 3 and 4.
The lessons will be held simultaneously both in class and by online streaming. At the beginning of the semester, each student must opt for face-to-face or online teaching. Shifts will be scheduled depending on the number of students who opt for the class mode.

Verification of learning

At the end of the course students will be subjected to a comprehensive final exam, articulated in a written multiple choice test, followed by an oral examination.
Based on the epidemiological context, the written tests can be replaced by: group monographic papers, oral exam, online written exam. In addition, intermediate exam tests can be eliminated.

Texts

Robbins: Le basi patologiche delle malattie. Elsevier;
Pontieri: Patologia Generale Piccin;
Stevens-Lowe: Patologia. Ambrosiana;
Woolf: Patologia Generale.Idelson -Gnocchi;
Rubin: Patologia. Ambrosiana.

Questionnaire and social

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