Select Academic Year:     2016/2017 2017/2018 2018/2019 2019/2020 2020/2021 2021/2022
Professor
GIUSEPPINA PICHIRI (Tit.)
ENRICO SANJUST
RAFFAELLA ISOLA
Period
First Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
ITALIANO 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[40/44]  PHYSIOTHERAPY [44/00 - Ord. 2017]  PERCORSO COMUNE 6 48
[40/56]  PROFESSIONAL EDUCATION [40/56 - Ord. 2015]  PERCORSO COMUNE 6 48

Objectives

Knowledge and understanding ability: The course aims to give at the student basic principles of the sciences and the biological thinking with associations to the knowledge of molecules and biochemical processes related to the structure and functions of cell organelles and tissues organization that make up the organs of the human body with particular attention to the locomotor and nervous system. The student will acquire the knowledge of the biological, biochemical and histological bases that characterize the human physiological and pathological processes.
Application abilities: The student should be able to know different levels of organization of life phenomenon and to use these biological information as a logic and an evolutionary approach (at molecular, cellular and organic level). The student should be also able to understand and make a relationship between structure and function of different organisms
Judgments ability: Through the acquisition of knowledge of biology, biochemistry and histology in particular understanding the evolution and the diversity life processes, the student should be also able to realized that in human as well as in other animals are present similar biological principles and that the biological research, at different organization levels, is important also for the scientific knowledge applied in the medical field
Communication ability: The student should acquire the ability to describe in an essential, comprehensive and correct terms biological processes and molecules involved in biomedical practice.
Learning ability: The theoretical basic knowledge of the processes involved in applied biology, biochemistry and histology, acquired and critically related to each other during the course, should develop the ability of the student to learn and use these biological information during subsequent studies and in his future professional activity.
Aims
Teaching aims are to provide critical and familial tools above cell and tissue issues that the student will find in others like Anatomy and Physiology, adding further clinical-pathological details.

Objectives

Knowledge and understanding ability: The course aims to give at the student basic principles of the sciences and the biological thinking with associations to the knowledge of molecules and biochemical processes related to the structure and functions of cell organelles and tissues organization that make up the organs of the human body with particular attention to the locomotor and nervous system. The student will acquire the knowledge of the biological, biochemical and histological bases that characterize the human physiological and pathological processes.
Application abilities: The student should be able to know different levels of organization of life phenomenon and to use these biological information as a logic and an evolutionary approach (at molecular, cellular and organic level). The student should be also able to understand and make a relationship between structure and function of different organisms
Judgments ability: Through the acquisition of knowledge of biology, biochemistry and histology in particular understanding the evolution and the diversity life processes, the student should be also able to realized that in human as well as in other animals are present similar biological principles and that the biological research, at different organization levels, is important also for the scientific knowledge applied in the medical field
Communication ability: The student should acquire the ability to describe in an essential, comprehensive and correct terms biological processes and molecules involved in biomedical practice.
Learning ability: The theoretical basic knowledge of the processes involved in applied biology, biochemistry and histology, acquired and critically related to each other during the course, should develop the ability of the student to learn and use these biological information during subsequent studies and in his future professional activity.
Aims
Teaching aims are to provide critical and familial tools above cell and tissue issues that the student will find in others like Anatomy and Physiology, adding further clinical-pathological details.

Prerequisites

High school knowledge of biology, general and organic chemistry.

Prerequisites

High school knowledge of biology, general and organic chemistry.

Contents

Applied Biology
• The general characteristics of living matterial:
structural and functional organization of biological units (viruses, prokaryotes, eukaryotes); levels of
biological organization, classification and interaction between organisms.
• The genetic information in prokaryotes and eukaryotes: DNA structure, properties, organization
genome. Chromatin and chromosomes. DNA duplication. Gene mutation.
• Genetic expression in prokaryotes and eukaryotes .: transcription RNA processes, maturation of pre-mRNA in eukaryotes the genetic code. Translation
• Biological reproduction in viruses, prokaryotic and eukaryotic cells: lytic cycle and lysogenic. binary fission. Mitosis.
• Sexual reproduction: meiosis and gametogenesis. Mitosis versus meiosis, the independent segregation
of chromosomes. Crossing over. The human fertilization.

Histology
Cytology
Generalities on: plasma membrane and transport across the membrane; membranous organelles; smooth and rough endoplasmic reticulum, Golgi apparatus, lysosomes, mitochondria, peroxisomes, proteasomes. Endocytosis and exocytosis. Cytoskeleton. Generalities on stem cells. A brief outline on apoptosis and necrosis.
Epithelial tissue
Generalities on epithelia; basement membrane and intercellular junctions; general structure of the epithelial lining and in particular the structure of the epidermis. General information on exocrine and endocrine glands.
Connective tissue
Connective tissue charachteristics: cells and intercellular substance; amorphous matrix and fibers; functions
of the connective tissue. Connective tissue classification.
Cartilaginous tissue: structural and functional characteristics; hyaline, fibrous and elastic cartilage; perichondrium.
Bone tissue: cells and intercellular substance; compact and cancellous bone; osteon; periosteum and endosteum; morpho-functional characteristics of the bone. Generalities on histogenesis of bone tissue.
Fluid connective tissue. Blood: characteristics, composition and generalities on the principles of immunity.
Nervous tissue
General organization of the nervous system. The nerve cell: structure and properties. Classification of neurons. Morphology of the neuron: description of cell soma, dendrites, axon. The axonal flow. The nerve fibers. The structure of a nerve. The chemical and electrical synapse morphology. The neuroglia in the CNS and PNS. Myelin sheath.
Muscle tissue
Muscle tissue: description of the skeletal muscle fiber, myofibril and sarcomere; the neuromuscular junction; notion of motor unit. Smooth muscle tissue: morphology. Striated muscle tissue of the heart: morphology. Muscle spindle.

Biochemistry:
Short Introduction to General and Organic Chemistry. Properties, Structures and Function of Amino Acids, Proteins, Lipids and Carbohydrates.
Vitamins. Introduction to Metabolism.
- Amino acids: structure and classification. Peptide bond
- Proteins: Structural organization levels and functions. Enzymatic proteins, Hb and Mb.
- Carbohydrates: structure of monosaccharides, disaccharides and polysaccharides.
- Lipids: classification, structure and properties. Notes on the structure of biological membranes.
- liposoluble vitamins
- Introduction to metabolism: role of ATP

Contents

Applied Biology
• The general characteristics of living matterial:
structural and functional organization of biological units (viruses, prokaryotes, eukaryotes); levels of
biological organization, classification and interaction between organisms.
• The genetic information in prokaryotes and eukaryotes: DNA structure, properties, organization
genome. Chromatin and chromosomes. DNA duplication. Gene mutation.
• Genetic expression in prokaryotes and eukaryotes .: transcription RNA processes, maturation of pre-mRNA in eukaryotes the genetic code. Translation
• Biological reproduction in viruses, prokaryotic and eukaryotic cells: lytic cycle and lysogenic. binary fission. Mitosis.
• Sexual reproduction: meiosis and gametogenesis. Mitosis versus meiosis, the independent segregation
of chromosomes. Crossing over. The human fertilization.

Histology
Cytology
Generalities on: plasma membrane and transport across the membrane; membranous organelles; smooth and rough endoplasmic reticulum, Golgi apparatus, lysosomes, mitochondria, peroxisomes, proteasomes. Endocytosis and exocytosis. Cytoskeleton. Generalities on stem cells. A brief outline on apoptosis and necrosis.
Epithelial tissue
Generalities on epithelia; basement membrane and intercellular junctions; general structure of the epithelial lining and in particular the structure of the epidermis. General information on exocrine and endocrine glands.
Connective tissue
Connective tissue charachteristics: cells and intercellular substance; amorphous matrix and fibers; functions
of the connective tissue. Connective tissue classification.
Cartilaginous tissue: structural and functional characteristics; hyaline, fibrous and elastic cartilage; perichondrium.
Bone tissue: cells and intercellular substance; compact and cancellous bone; osteon; periosteum and endosteum; morpho-functional characteristics of the bone. Generalities on histogenesis of bone tissue.
Fluid connective tissue. Blood: characteristics, composition and generalities on the principles of immunity.
Nervous tissue
General organization of the nervous system. The nerve cell: structure and properties. Classification of neurons. Morphology of the neuron: description of cell soma, dendrites, axon. The axonal flow. The nerve fibers. The structure of a nerve. The chemical and electrical synapse morphology. The neuroglia in the CNS and PNS. Myelin sheath.
Muscle tissue
Muscle tissue: description of the skeletal muscle fiber, myofibril and sarcomere; the neuromuscular junction; notion of motor unit. Smooth muscle tissue: morphology. Striated muscle tissue of the heart: morphology. Muscle spindle.

Biochemistry:
Short Introduction to General and Organic Chemistry. Properties, Structures and Function of Amino Acids, Proteins, Lipids and Carbohydrates.
Vitamins. Introduction to Metabolism.
- Amino acids: structure and classification. Peptide bond
- Proteins: Structural organization levels and functions. Enzymatic proteins, Hb and Mb.
- Carbohydrates: structure of monosaccharides, disaccharides and polysaccharides.
- Lipids: classification, structure and properties. Notes on the structure of biological membranes.
- liposoluble vitamins
- Introduction to metabolism: role of ATP

Teaching Methods

Lectures, with video assistance and slides.

Verification of learning

ORAL EXAMINATION.
The knowledge of the course topics, the ability to connect different topics, the expressive ability, the use of appropriate terminology and the ability to synthesize arguments will be assessed.

Final valutation.
The final valutation will take into account various factors:
Quality of knowledge, skills, competences possessed and / or manifested:
a) appropriateness, propriety and congruence of knowledge
b) appropriateness, propriety and congruence of skills
c) appropriateness, propriety and congruence of expertise.
Exhibition mode:
a) Expressive ability
b) Appropriate use of the specific language of the discipline
c) Logical competences and consequentiality in the connection of contents
Relationship qualities:
a) Willingness to exchange and interact with the teacher
Personal qualities:
a) critical spirit
b) self-assessment capacity
The valutation can be:
a) sufficient (from 18 to 20/30)
The candidate demonstrates few and a superficial level of acquired knowledges, many gaps. Modest expressive expertise but still sufficient to support a coherent dialogue; logical ability and consequentiality in the connection of elementary topics, poor synthesis ability and poor interaction with the teacher during the examination.
b) Discreet (from 21 to 23/30)
The candidate demonstrates fairly good knowledge acquired with few gaps. Expressive expertise more than enough to support a coherent dialogue; logical skills and consequentiality in the connection of moderate complexity, more than sufficient ability to synthesize and discreet interaction with the teacher during the examination.
c) Good (24 to 26):
The candidate demonstrates a rather broad background of notions, moderate depth, with small gaps. Remarkable expressive capacity and high ability to use scientific language; excellent dialogue skills and critical spirit well detectable; good synthesis ability.
d) Excellent (from 27 to 29/30):
The candidate demonstrates a very extensive knowledge, with few marginal gaps. Satisfactory expressive capacity and significant ability to use scientific language; excellent dialogue and critical skills; high synthesis capacity.
e) Excellent (30):
The candidate demonstrates a very extensive knowledge with some irrelevant gaps. High expressive ability and high capacity to use scientific language; excellent dialogue and critical skills; high synthesis capacity.
Honors (lode) will be attributed to candidates with clearly higher capacities.

Texts

Biologia Applicata: Elementi di Biologia, Solomon et al. EdiSES
Altro materiale messo a disposizione:
Copia delle slides delle lezioni

Biochimica: D. L. Nelson, M.M. Cox, Introduzione alla Biochimica di Lehninger. Zanichelli
DAndrea, Biochimica Essenziale, edises.
M. Samaja -R.Paroni, Chimica e Biochimica. Piccin
P. C. Champe, R. A. Harvey, D. R. Ferrier, Le Basi della Biochimica. Zanichelli

Istologia: Istologia per le lauree triennali e magistrali.Edizioni Idelson Gnocchi
Or, in substitution: Carinci et al. Citologia & Istologia umana. Idelson Gnocchi
Texts and atlases are available for consultation in the Biomedical Library.

Texts

Biologia Applicata: Elementi di Biologia, Solomon et al. EdiSES
Other didactic material :
slides and videos

Biochimica: D. L. Nelson, M.M. Cox, Introduzione alla Biochimica di Lehninger. Zanichelli
DAndrea, Biochimica Essenziale, edises.
M. Samaja -R.Paroni, Chimica e Biochimica. Piccin
P. C. Champe, R. A. Harvey, D. R. Ferrier, Le Basi della Biochimica. Zanichelli

Istologia:Istologia per le lauree triennali e magistrali.Edizioni Idelson Gnocchi
Or: Carinci et al. Citologia & Istologia umana. Idelson Gnocchi
Testi e atlanti are available in the Biblioteca Biomedica.

More Information

Addresses and student appointments schedule:
Biologia: Dott.ssa Pichiri Giuseppina (Biologia Applicata), Dip. di Scienze Mediche e Sanità Pubblica, Sez. di Anatomia Patologica, Ospedale “San Giovanni di Dio”, via Ospedale 54, Cagliari, tel 07051092238
pichiri@unica.it
Biochimica
Prof. Enrico Sanjust
Mail: sanjust@unica.it
Sede: Dipartimento Scienze Biomediche – Cittadella Universitaria
Tel: 070675-4518
Istologia:
Dott.ssa Raffaella Isola
Dipartimento di Scienze Biomediche
Sezione di Citomorfologia
Cittadella Universitaria di Monserrato
09042 Monserrato (CA)
Tel. 070.675.4041 opp. 070.675.4025 - e-mail: isola@unica.it
Teachers will receive students by appointment.

More Information

Addresses and student appointments schedule:
Biologia: Dott.ssa Pichiri Giuseppina (Biologia Applicata), Dip. di Scienze Mediche e Sanità Pubblica, Sez. di Anatomia Patologica, Ospedale “San Giovanni di Dio”, via Ospedale 54, Cagliari, tel 07051092238
pichiri@unica.it
Biochimica
Prof. Enrico Sanjust
Mail: sanjust@unica.it
Sede: Dipartimento Scienze Biomediche – Cittadella Universitaria
Tel: 070675-4518
Istologia:
Dott.ssa Raffaella Isola
Dipartimento di Scienze Biomediche
Sezione di Citomorfologia
Cittadella Universitaria di Monserrato
09042 Monserrato (CA)
Tel. 070.675.4041 opp. 070.675.4025 - e-mail: isola@unica.it
Teachers will receive students by appointment.

Questionnaire and social

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