MC/0825 - CHIMICA, BIOCHIMICA E BIOLOGIA
Academic Year 2021/2022
Free text for the University
RENATO ROBLEDO (Tit.)
- Teaching style
- Lingua Insegnamento
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Knowledge and understanding:
Understanding of the molecular bases and biochemical mechanisms that regulate cellular metabolic activity. The student has to know the characteristics of the biomolecules, structure, function, interactions and metabolism and their behavior in biological systems.
Applying knowledge and understanding:
The student will be able to:
-apply the chemical bases of the discipline and apply the acquired knowledge as a starting point for the study of subsequent biological disciplines.
- apply the acquired knowledge to understanding the structure-function relationship of the biomolecules, to understanding the metabolic processes underlying the production and conservation of the chemical energy and its transformations.
The student will be able to discern between fundamental and complementary topics, identifying the logical thread underlying the rational study of Medical Chemistry and Biochemistry avoiding the merely mnemonic acquisition of definitions, schemes, equations, graphs and structural formulas.
The student will be able to explain the course topics using formalism, language and vocabulary typical of the disciplines. Interact with the teacher arguing the salient points of the study program, with the necessary detail.
Ability to learn:
The interaction with the teacher, the teaching material (lesson slides), and the consultation of the suggested books will provide the student with the tools necessary for the fruitful, reasoned and non-mnemonic learning of the discipline. Learning the basic concepts of Medical Chemistry and Biochemistry will consolidate the student's scientific culture, allowing him to independently develop an opinion in the deepening of knowledge in his own working environment.
Knowledge of the nature and functions of genetic material in eukaryotes, understanding of the mechanisms and modes of transmission of genes and the relationships between genotype and phenotype. Learning of the basic methodologies used in genetic analysis and ability to use the knowledge acquired in the analysis of experimental data. At the end of the course, students will have to demonstrate knowledge of the basic mechanisms of biochemistry and genetics, and will also need to be able to apply the concepts.
Basic scientific knowledge of Chemistry.
Good knowledge of the structure and function of the eukaryotic cell. Good knowledge of the basic mechanisms of reproduction (mitosis and meiosis).
Structure of matter: mixtures, pure substances, elements and compounds, chemical equations. Human body elements composition. Chemical bond. Water and weak interactions in aqueous systems. Equilibria in solution. Acid-base balance, salts and buffer systems. Biological oxide-reductions. The chemistry of carbon: hydrocarbons and functional groups, alcohols, phenols and thiols, ethers, aldehydes and ketones, amines, carboxylic acids, esters and amides. Isomerism. Multifunctional compounds: biomolecules. Structure and function of carbohydrates (monosaccharides, disaccharides, polysaccharides). Structure and function of nucleotides. Structure and function of lipid (fatty acids, storage lipids, structural lipids in membranes, cholesterol) Structure and function of proteins (aminoacids and peptide bond; fibrous and globular proteins; myoglobin and haemoglobin; oxygen and carbon dioxide transport; immunoglobulins). Enzymes: general concepts, enzyme kinetics, coenzymes (water-soluble vitamins) enzyme activity regulation. Metabolism: endergonic and exergonic reactions; catabolic and anabolic pathways; energy production and consumption in metabolism; role of ATP and other phosphorilated compounds. Carbohydrate, lipid and aminoacid metabolic pathways.
Molecular basis of inheritance: composition, structure and function of DNA. Genome organization. Genes and chromosomes. Eukaryotic DNA replication. Structure and functions of RNA. Gene expression: transcription processes and translation. Genetic code. Variation of genetic material. Gene mutations. Changes in structure and in the number of chromosomes. Somatic and germinal mutations. Mutations and evolution. Reproduction and cell cycle. Cell cycle control. Signal transduction.
Teaching will be delivered mainly in presence, integrated and "expanded" with online strategies, in order to guarantee its use in an innovative and inclusive way.
Lectures through power-point presentations for both biochemistry and genetics, and exercises on the analysis and resolution of genetic problems.
Verification of learning
The knowledge and ability acquired by students will be assessed through written test or oral interview. The test with positive score (with a mark from eighteen to thirty) will be part of the final assessment of the integrated course. The final evaluation is obtained from the weighted average of the marks reported in the two modules.
The final assessment is made on the basis of ongoing assessment and oral exam.
It will be assessed:
quality of the students’ knowledge, skills, competences and ability to apply knowledge and understanding (appropriateness, correctness and consistency)
appropriate use of the specific language of the discipline, logical skills and inherent consequentiality in communicating, logic capacity and consequential of contents, ability to connect different subjects by finding the common points.
The judgment can be:
Sufficient (from 18 to 20/30)
The candidate demonstrates little acquisition of theoretical knowledge, superficial level, many gaps. Modest communicative abilities, but still sufficient to support a coherent dialogue, logical capacity and consequentiality in fitting the subjects of elementary level; poor capacity of synthesis, scanty interaction with the teacher during the interview.
Moderate (21 to 23)
The applicant demonstrates a moderate acquisition of knowledge but lack of expatiation, a few gaps; communicative abilities more than sufficient to support a coherent dialogue; acceptable mastery of the scientific language, logical capacity and consequentiality in fitting the subjects of moderate complexity, good enough capacity of synthesis.
Good (24 to 26)
The candidate demonstrates a rather large wealth of knowledge, moderate in-depth, with some gaps; satisfactory mastery of the communicative abilities and meaningful scientific language; dialogical ability and critical thinking well detectable, good capacity of synthesis.
Outstanding (27 to 29)
The candidate demonstrates a very extensive wealth of notions, high in-depth, with marginal gaps; remarkable ability in communicating and high mastery of scientific language; remarkable dialogical capacity, good competence and relevant aptitude for logical synthesis, high capacity of synthesis.
The candidate demonstrates a wealth of very extensive and in-depth knowledge, no gaps, high capacity and high mastery in communicating through the scientific language; excellent dialogical ability and marked aptitude to make connections among different subjects, excellent ability to synthesize.
The praise is attributed to the candidates clearly above average without notional, expressive, conceptual, and logical limits.
Roberti-Bistocchi-Antognelli-Talesa/Chimica e Biologia per le professioni sanitarie/McGrawHill
Samaja-Paroni/Chimica e Biochimica/Piccin
Stefani-Taddei/Chimica, Biochimica e Biologia applicata/Zanichelli
Solomon et al: Elementi di Biologia. Edises
Plopper: Biologia della cellula. Zanichelli
The PowerPoint presentations of lectures are available.
The teachers are available to meet students by appointment, previous email contact.