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Professor
ANDREA PERRA (Tit.)
MARTA ANNA KOWALIK
ALDO MANZIN
Period
First Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[50/21]  PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY [21/00 - Ord. 2014]  PERCORSO COMUNE 10 80

Objectives

MICROBIOLOGY MODULE
KNOWLEDGE AND UNDERSTANDING CAPACITY
During the course of microbiology and clinical microbiology, the student will have the opportunity to understand and understand different knowledge such as:
• Structure, morphology and classification of bacteria.
• Metabolism, pathogenicity and bacterial genetics.
• Mechanism of action of antibiotics and chemotherapeutics.
• Structure, morphology, replication and classification of viruses.
• Pathogenic action of viruses and their role in oncogenesis.
• Mechanism of action of antiviral drugs.
• General characteristics of fungi and protozoa.
• Characteristics of the main species of microbes that affect human and animal pathology.
• Immune response to infections.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING (COMPETENCE)
• The basic knowledge of Microbiology will allow the student to understand the relationships that the microorganisms establish with the host in normal and pathological conditions and understand the microbial factors that contribute to maintaining the homeostatic balance of the organism.
• Microbiology elements will be useful for understanding infectious diseases, their therapy and microbiological testing.
• Acquire expertise on the use of anti-bacterial d intiviral drugs

JUDGMENT AUTONOMY
• The student, after learning the principles of microbiology, will be able, independently, to apply this knowledge in any field (medical, chemical, pharmacological, etc).
• Will be able to interpret and solve problems related to these issues.
COMMUNICATION SKILLS
The student with these microbiological notions will have the opportunity to communicate their knowledge with appropriate formal language and written communications.
LEARNING ABILITY
The knowledge of Microbiology will be useful to the student to continue, with absolute autonomy, the learning and knowledge of the subjects expected in the following years of the course.

PATHOLOGY MODULE
KNOWLEDGE AND UNDERSTANDING CAPACITY
The course is specifically intended to provide students with the basic pathological principles by relating basic science with main pathogenetic mechanisms.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING (COMPETENCE)
At the end of the course students should have a sound knowledge of the fundamental biological and pathological mechanisms underlying human diseases.
COMMUNICATION SKILLS
The students should be able to use and understand the medical terminology
LEARNING ABILITY
Emphasis will be also placed on the applications of molecular biology and histopathology and their relevance in the understanding of the origin of diseases.

Prerequisites

The student will have a greater understanding of microbiology, clinical microbiology and general pathology if he has a sound knowledge of biology, anatomy, chemistry and biochemistry

Contents

The course of Microbiology and General Pathology is 10 CFU: 5 of Microbiology and 5 of General Pathology. Each ECTS corresponds to 8 hours of lectures for a total teaching load of 80 hours of lessons.
MICROBIOLOGY MODULE
The 40 hours of the Microbiology module will be developed through lectures supported by Power Point presentations, to help the student to follow with greater attention. These presentations will not be provided to students who will have to study on one of the recommended Microbiology texts.
Approximate program
12 hours: introduction to the subject. Brief history of microbiology. Differences between eukaryotic and prokaryotic cells. Structure, chemical composition and function of the bacterial cytoplasmic membrane. Structure, chemical composition, function and synthesis of the bacterial wall, cytoplasmic organelles, ribosomes, nucleocapsid, layer S, pili, flagella. Bacterial genetics (genetic recombination, transformation, transduction, conjugation). Bacterial metabolism, growth curve, nutritional needs
1 hour: normal flora of the human organism. Sterilization and disinfection
2 hours: principles of immunology: antigen, hapten, antibodies, immune response
2 hours: bacterial pathogenicity
3 hours: mechanism of action of antibiotics and chemotherapeutics
8 hours: main classes of bacteria and their pathologies
2 hours: essential principles of fungi
2 hours: essential principles of pests
3 hours: morphology, chemical structure, virus replication strategies.
5 hours: main classes of viruses and their pathologies

PATHOLOGY MODULE
10 hours will be dedicated to the study of cell adaptation, cell injuty and repair; 15 hours will be dedicated to the inflammatory process and the wound healing; 15 hours will be dedicated to cell cycle controll, oncology and genetic diseases.
Programm:
Cell injury and cell death: Necrosis and apoptosis.
Cellular adaptation of growth and differentiation: Hyperplasia, hypertrophy, atrophy, metaplasia.
Intracellular accumulation: Lipids, proteins, glycogen, pigments.
Control of normal cell growth: cell cycle and the regulation of cell division.
Acute and chronic inflammation.
Vascular changes, cellular events, chemical mediators of inflammation.
Non-inflammatory edema
Systemic effects of inflammation.
Tissue repair and fibrosis.
Wound healing.
Neoplasia. Epidemiology: Cancer incidence. Definition and terminology.
Biology of tumor growth (angiogenesis, progression and heterogeneity, invasion and metastasis).
Carcinogenic agents and their cellular interaction.
DNA damage and repair.
Molecular basis of cancer (Oncogenes, cancer suppressor genes, molecular basis of multistep carcinogenesis).
Genetic disorders.
Mendelian disorders (autosominal dominant, recessive and X-linked).
Biochemical and molecular basis of single-gene disorders.
Cytogenetic disorders.
Diseases of immunity.
Mechanism of immunologic tissue injury: hypersensitivity reactions.
Atherosclerosis: pathogenesis risk factors, complications.
Thrombosis, ischemia/reperfusion injury.
Qualitative and quantitative blood cells alterations.

Teaching Methods

MICROBIOLOGY MODULE
The course lasts about 3 months (4 hours of lessons per week), 40 hours of lectures with the help of Power Point presentations.
To meet the specific teaching needs related to the epidemiological situation, teaching will be delivered simultaneously both in presence and online, thus outlining a mixed teaching that can be enjoyed in university classrooms but also at a distance. At the beginning of the semester, each student can opt, with a binding choice, for face-to-face or distance teaching. Depending on the availability of the classrooms and the number of students who will opt for the attendance mode, there may still be a shift for actual classroom access.
PATHOLOGY MODULE
Duration and Didactic Method:
The course lasts about 9-10 weeks (from 4 to 6 hours of lessons per week) and is done through lectures with the aid of electronic presentations and other audio or visual information media. The lessons will be held simultaneously both in class and by online streaming. At the beginning of the semester, each student must opt for face-to-face or online teaching. Shifts will be scheduled depending on the number of students who opt for the class mode.

Verification of learning


MICROBIOLOGY MODULE
The final test is performed after the students have taken the exams of Animal Biology, Human Anatomy, Biochemistry, General Physiology. The student's learning will be evaluated through an oral exam

PATHOLOGY MODULE
Only students that have already acquired the credits from the propaedeutic courses (Biology, Anatomy, Biochemistry, Physiology) can be evaluated by an oral examination, a written test or both.
Based on the epidemiological context, the written tests can be replaced by: group monographic papers, oral exam, online written exam. In addition, intermediate exam tests can be eliminated.
FINAL VOTE:
As foreseen by the didactic regulation of the Degree Course for the courses divided into coordinated modules, the final assessment of the student's profit, for the attribution of the mark, will be done collectively by the course owners, based on the overall assessment of the tests supported by the student.
Based on the epidemiological situation at the time of the assessment, the written tests may be replaced by different verification methods, for example: individual or group work (term papers), oral interviews, remote written tests using computer aids (moodle, Teams, etc. .), or completely eliminated in the case of intermediate checks.

Texts

Microbiology
MICROBIOLOGIA FARMACEUTICA
a cura di Carlone e Pompei
Ed. EDISES, Napoli

General Pathology:
Robbins: Le basi patologiche delle malattie. 8 ed.
Pontieri: Patologia Generale. Piccin;
Stevens-Lowe: Patologia. Ambrosiana;
Rubin: Patologia. Ambrosiana.

Questionnaire and social

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