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Professor
OSVALDO GIORGI (Tit.)
Period
First Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[50/22]  PHARMACY [22/00 - Ord. 2014]  PERCORSO COMUNE 8 64

Objectives

The main objective of the Course is to provide knowledge of:

(1) the major classes of drugs and their mechanisms of action at the molecular, cellular and systemic levels
(2) the principles of Pharmacokinetics (drug absorption, distribution, metabolism and excretion)
(3) the effects of drugs on the functions of the central and autonomic nervous systems, the cardiovascular and respiratory systems, as well as the gastrointestinal tract.

Another aim of the course is to provide understanding of the theoretical principles of pharmacological methods applied to the in vitro and vivo characterization of drug effects

Prerequisites

In order to take the final examination of General Pharmacology, the student must:
• have attended the Biochemistry course
• have passed the final Organic Chemistry and Physiology examinations.



Contents

Program of the Course

DRUG-RECEPTOR INTERACTIONS
LIGAND OPERATED CHANNELS
G PROTEIN ASSOCIATED RECEPTORS
REGULATION OF INTRACELLULAR CALCIUM SIGNALING
IONIC CHANNELS
MEMBRANE PUMPS AND TRANSPORTER PROTEINS
NEUROTRANSPORTERS
NEUROTRANSMITTER EXOCYTOSIS
CHOLINERGIC TRANSMISSION
ADRENERGIC TRANSMISSION
DOPAMINERGIC TRANSMISSION
SEROTONERGIC TRANSMISSION
GABAERGIC TRANSMISSION
GLUTAMATERGIC TRANSMISSION
OPIOIDERGIC TRANSMISSION
MECHANISMS OF ACTION OF ANTIEPILEPTIC DRUGS
CELLULAR BASIS OF PHARMACOKINETICS
ROUTES OF ADMINISTRATION AND ABSORPTION OF DRUGS
DRUG DISTRIBUTION
DRUG METABOLISM
DRUG ELIMINATION

Teaching Methods

The course will last 10 weeks and will consist of six 1 hour long lectures per week.

Verification of learning

The students must take and pass 2 partial written tests to be admitted to the final oral examination.

The final exam consists of an oral test. The student will discuss orally several topics proposed by the teacher, using, where necessary, schemes / graphic representations. Knowledge of the topics of the course, the ability to link between different topics, the expressive capacity, the use of appropriate terminology, the ability to synthesize concepts will be evaluated.
The final grade takes into account several factors:
Quality of the knowledge, skills and competences:
a) appropriateness, accuracy and consistency of knowledge
b) appropriateness, accuracy and consistency of skills
c) appropriateness, accuracy and consistency of competences
Exposition mode:
a) Capacity of expression;
b) Proper use of the specific language of the discipline;
c) Logical capacity and consequentiality in the fitting of the contents;
e) Ability to connect different arguments by finding the common points and establish a consistent overall design, ie taking care of structure, organization and logical connections of speech exposition;
f) Ability to summarize.
Relational qualities:
Capability to interact with the teacher during the interview.
Personal qualities:
a) critical capability;
b) ability to self-evaluation.
Consequently, the judgment can be:
a) Fair (18 to 20/30)
The candidate demonstrates little knowledge acquired, superficial level, many gaps. Expressive abilities modest, but still sufficient to support a coherent dialogue; logical capacity and consequentiality in the fitting of the subjects at elementary level; poor capacity for synthesis, lack of interaction with the teacher during the interview.
b) Moderate (21 to 23)
The applicant demonstrates a discreet acquisition of knowledge but lack of depth, with a few gaps; expressive abilities more than sufficient to support a coherent dialogue; acceptable mastery of the language of science, logical capacity and consequentiality in the fitting of the arguments of moderate complexity, more than enough capacity for synthesis and the ability to graphic expression acceptable.
c) Good (24 to 26)
The candidate demonstrates a rather large knowledge, moderate depth, with small gaps; satisfactory mastery of the expressive capabilities and significant scientific language; dialogical ability and critical thinking well detectable, good capacity for synthesis and ability to graphic expression more than acceptable.
d) Outstanding (27 to 29)
The candidate demonstrates a very extensive knowledge, well depth, with marginal gaps; remarkable powers of expression and high mastery of scientific language; remarkable capacity of dialogue, good competence and relevant aptitude for logic synthesis, high capacity for synthesis and graphic expression.
e) Excellent (30)
The candidate demonstrates a very extensive and in-depth knowledge, gaps irrelevant, high capacity and high mastery of the expressive language of science; excellent capacity of dialogue,aptitude to make connections between different subjects, excellent ability to synthesize and very familiar with graphic expression.
The praise is attributed to the candidates clearly above average, and whose notional, expressive, conceptual, and logical limits, if any, as a whole are completely irrelevant.

Texts

Recommended text book:

RANG & DALE “FARMACOLOGIA”. VIII EDIZIONE. EDRA S.p.A, 2016.

Additional reference text books:

F. CLEMENTI, G. FUMAGALLI “FARMACOLOGIA GENERALE E MOLECOLARE” V EDIZIONE. EDRA S.p.A., 2018 (provides detailed descriptions of the molecular pharmacodynamic mechanisms of drugs).

H. HITNER, B. NAGLE “PRINCIPI DI FARMACOLOGIA. Classificazione – Interazioni – Indicazioni cliniche”. ZANICHELLI. I° Edizione, 2014 (complementary text book of the previous one that provides brief descriptions of the systemic effects of drugs).

L. L. BRUNTON, R. HILAL-DANDAN, B. C. KNOLLMANN “GOODMAN & GILMAN LE BASI FARMACOLOGICHE DELLA TERAPIA”. XIII° EDIZIONE. ZANICHELLI, 2019.

More Information

The students will receive the files in PDF format containing the slides used in all the lectures of the course

Questionnaire and social

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